Biochemistry Department Publications 2019
Abdel-Rahman N, Sharawy MH, Megahed N, El-Awady MS. Vitamin D3 abates BDL-induced cholestasis and fibrosis in rats via regulating Hedgehog pathway. Toxicol Appl Pharmacol. 2019;380:114697.
https://doi.org/10.1016/j.taap.2019.114697
Abdelrahman RS, Abdel-Rahman N. Dimethyl fumarate ameliorates acetaminophen-induced hepatic injury in mice dependent of Nrf-2/HO-1 pathway. Life Sci. 2019;217:251-260.
https://doi.org/10.1016/j.lfs.2018.12.013
Al-Dossari MH, Fadda LM, Attia HA, Hasan IH, Mahmoud AM. Curcumin and Selenium Prevent Lipopolysaccharide/Diclofenac-Induced Liver Injury by Suppressing Inflammation and Oxidative Stress. Biol Trace Elem Res. 2020;196(1):173-183.
https://doi.org/10.1007/s12011-019-01910-4
Al-Gayyar MMH, Bagalagel A, Noor AO, Almasri DM, Diri R. The therapeutic effects of nicotinamide in hepatocellular carcinoma through blocking IGF-1 and effecting the balance between Nrf2 and PKB. Biomed Pharmacother. 2019;112:108653.
https://doi.org/10.1016/j.biopha.2019.108653
Awad AE, Ebrahim MA, Eissa LA, El-Shishtawy MM. Dickkopf-1 and Amphiregulin as Novel Biomarkers and Potential Therapeutic Targets in Hepatocellular Carcinoma. Int J Hematol Oncol Stem Cell Res. 2019;13(3):153-163.
https://doi.org/10.18502/ijhoscr.v13i3.1275
Eisa NH, Jilani Y, Kainth K, et al. The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis. J Biol Chem. 2019;294(14):5246-5260.
https://doi.org/10.1074/jbc.RA118.006597
El-Hawary SS, Sayed AM, Mohammed R, et al. Bioactive Brominated Oxindole Alkaloids from the Red Sea Sponge Callyspongia siphonella. Mar Drugs. 2019;17(8):465. Published 2019 Aug 9.
https://doi.org/10.3390/md17080465
El-Mesery, M., Rosenthal, T., Rauert-Wunderlich, H. et al. The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death. Cell Death Dis 10, 611 (2019).
https://doi.org/10.1038/s41419-019-1860-2
Elmasry K, Ibrahim AS, Abdulmoneim S, Al-Shabrawey M. Bioactive lipids and pathological retinal angiogenesis. Br J Pharmacol. 2019;176(1):93-109. https://doi.org/10.1111/bph.14507
Elshaer RE, Tawfik MK, Nosseir N, et al. Leflunomide-induced liver injury in mice: Involvement of TLR4 mediated activation of PI3K/mTOR/NFκB pathway. Life Sci. 2019;235:116824.
https://doi.org/10.1016/j.lfs.2019.116824
Elsherbiny NM, Abdel-Mottaleb Y, Elkazaz AY, et al. Carbamazepine Alleviates Retinal and Optic Nerve Neural Degeneration in Diabetic Mice via Nerve Growth Factor-Induced PI3K/Akt/mTOR Activation. Front Neurosci. 2019;13:1089. Published 2019 Nov 1.
https://doi.org/10.3389/fnins.2019.01089
FOUAD, D., BADR, A. & ATTIA, H. A. Hepatoprotective activity of raspberry ketone is mediated via inhibition of the NF-kappaB/TNF-alpha/caspase axis and mitochondrial apoptosis in chemically induced acute liver injury. Toxicol Res (Camb).2019;
https://doi.org/10.1039/C9TX00068B
Hamdan, A.M., Al-Gayyar, M.M., Shams, M.E.E. et al. Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives. Sci Rep 9, 7026 (2019).
https://doi.org/10.1038/s41598-019-43568-x
Helmy SA, El-Mesery M, El-Karef A, Eissa LA, El Gayar AM. Thymoquinone upregulates TRAIL/TRAILR2 expression and attenuates hepatocellular carcinoma in vivo model. Life Sci. 2019;233:116673.
https://doi.org/10.1016/j.lfs.2019.116673
Hussein AM, Eldosoky M, El-Shafey M, et al. Effects of GLP-1 Receptor Activation on a Pentylenetetrazole-Kindling Rat Model. Brain Sci. 2019;9(5):108. Published 2019 May 14.
https://doi.org/10.3390/brainsci9050108
Hussein AM, Eldosoky M, El-Shafey M, et al. Effects of metformin on apoptosis and α-synuclein in a rat model of pentylenetetrazole-induced epilepsy. Can J Physiol Pharmacol. 2019;97(1):37-46.
https://doi.org/10.1139/cjpp-2018-0266
Mosaad YM, Khashaba M, Darwish A, et al. ARID5B rs10821936 and rs10994982 gene polymorphisms and acute lymphoblastic leukemia: relation to disease susceptibility and outcome. Pediatr Hematol Oncol. 2019;36(6):365-375.
https://doi.org/10.1080/08880018.2019.1649333
Mostafa AS, Bayoumi WA, El-Mesery M, Elgaml A. Molecular Design and Synthesis of New 3,4-Dihydropyrimidin-2(1H)-Ones as Potential Anticancer Agents with VEGFR-2 Inhibiting Activity. Anticancer Agents Med Chem. 2019;19(3):310-322.
https://doi.org/10.2174/1871520618666180717125906
Pinkerton DM, Chow S, Eisa NH, et al. Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor. Chemistry. 2019;25(6):1451-1455.
https://doi.org/10.1002/chem.201805420
Salama YA, El-Karef A, El Gayyar AM, Abdel-Rahman N. Beyond its antioxidant properties: Quercetin targets multiple signalling pathways in hepatocellular carcinoma in rats. Life Sci. 2019;236:116933.
https://doi.org/10.1016/j.lfs.2019.116933
Scheurer MJJ, Brands RC, El-Mesery M, et al. The Selection of NFκB Inhibitors to Block Inflammation and Induce Sensitisation to FasL-Induced Apoptosis in HNSCC Cell Lines Is Critical for Their Use as a Prospective Cancer Therapy. Int J Mol Sci. 2019;20(6):1306. Published 2019 Mar 15.
https://doi.org/10.3390/ijms20061306
Tawfik A, Mohamed R, Elsherbiny NM, DeAngelis MM, Bartoli M, Al-Shabrawey M. Homocysteine: A Potential Biomarker for Diabetic Retinopathy. J Clin Med. 2019;8(1):121. Published 2019 Jan 19.
https://doi.org/10.3390/jcm8010121
Valle ML, Dworshak J, Sharma A, Ibrahim AS, Al-Shabrawey M, Sharma S. Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells. Exp Eye Res. 2019;178:27-36.
https://doi.org/10.1016/j.exer.2018.09.009
Imad Eddin M. Zabad, Mohamed N. Amin, Mamdouh M. El-Shishtawy. Protective effect of vanillin on diabetic nephropathy by decreasing advanced glycation end products in rats. Life Sciences,2019;239:117088.
https://doi.org/10.1016/j.lfs.2019.117088.
Zabad OM, Samra YA, Eissa LA. P-Coumaric acid alleviates experimental diabetic nephropathy through modulation of Toll like receptor-4 in rats. Life Sci. 2019;238:116965.
https://doi.org/10.1016/j.lfs.2019.116965
Zeidan MA, Mostafa AS, Gomaa RM, et al. Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors. Eur J Med Chem. 2019;168:315-329.
https://doi.org/10.1016/j.ejmech.2019.02.050
Elmansi AM, Awad ME, Eisa NH, et al. What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands. Pharmacol Ther. 2019;198:90-108.
https://doi.org/10.1016/j.pharmthera.2019.02.005
Abo El-Magd NF, El-Karef A, El-Shishtawy MM, Eissa LA. Glycyrrhizin and Omega-3 fatty acids have hepatoprotective roles through toll-like receptor. Egyptian Journal of Basic and Applied Sciences. 2019; 82-98.
https://doi.org/10.1080/2314808X.2019.1669111
Nesma A. Abd Elrazik, Mohamed El-Mesery, Amro El-Karef, Laila A. Eissa, Amal M El Gayar. Chlorogenic acid potentiates antitumor effect of doxorubicin through upregulation of death receptors in solid Ehrlich carcinoma model in mice. Egyptian Journal of Basic and Applied Sciences. 2019;158-12.