Noura H. Abou-Taleb*, Dina T. El-Sherbiny, Nahed M. El-Enany, and Hussein I. El-Subbagh. Multiobjective optimization of microemulsion- thin layer chromatography with image processing as analytical platform for determination of drugs in plasma using desirability functions. Journal of Chromatography A 2020, 1619, 460945. https://doi.org/10.1016/j.chroma.2020.460945

Noura H. Abou-Taleb*, Nahed M. El-Enany, Dina T. El-Sherbiny, & Hussein I. El-Subbagh. Digitally enhanced thin layer chromatography for simultaneous determination of norfloxacin and tinidazole with the aid of Taguchi orthogonal array and desirability function approach: Greenness assessment by analytical Eco-Scale. Journal of Separation Science 2020, 43(6), 1195–1202. https://doi.org/10.1002/jssc.201900997

Noura H. Abou-Taleb*, Dina T. El-Sherbiny, Nahed M. El-Enany, and Hussein I. El-Subbagh. A novel application of deep eutectic solvents in quantitative nuclear magnetic resonance using grey relational analysis for multi-response optimization. Chemometrics and Intelligent Laboratory Systems 2020, 206, 104125. https://doi.org/10.1016/j.chemolab.2020.104125

Amal A. El-Masry, Mohammed E. A. Hammouda, Dalia R. El-Wasseef, and Saadia M. El-Ashry. Eco-Friendly Green Liquid Chromatographic Separations of a Novel Combination of Azelastine and Fluticasone in the Presence of their Pharmaceutical Dosage form Additives. Current Analytical Chemistry 2020, 16(3), 277–286. https://doi.org/10.2174/1573411014666180727130722

Ashraf N. Abdalla, Mohamed E. Abdallah, Akhmed Aslam, Ammar Bader, Antonio Vassallo, Nunziatina D. Tommasi, Waleed H. Malki, Ahmed M. Gouda, Mohammed H. Mukhtar, Mahmoud Z. El-Readi, Hamad M. Alkahtani, Alaa A. M. Abdel-Aziz, and Adel S. El-Azab. Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors. Molecules 2020, 25(9). https://doi.org/10.3390/MOLECULES25092220

Alaa A. M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Almehizia, and Ibrahim A. Al-Suwaidan.  Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 610–621. https://doi.org/10.1080/14756366.2020.1722120

Alaa A. M. Abdel-Aziz, Adel S. El-Azab, Hazem A. Ghabbour, and Ahmad J. Obaidullaha. Crystal structure of (E)-N′-((4-aminophenyl) sulfonyl)-N, N-dimethylformimidamide, C9H13N3O2S. Zeitschrift Fur Kristallographie - New Crystal Structures 2020, 235(2), 483–484. https://www.degruyter.com/document/doi/10.1515/ncrs-2019-0781/html

Alaa A. M. Abdel-Aziz, Adel S. El-Azab, Hazem A. Ghabbour, and Ahmad J. Obaidullaha. Crystal structure of (E)-N′-((4-aminophenyl) sulfonyl)-N,N-dimethylformimidamide, C9H13N3O2S. Zeitschrift Fur Kristallographie - New Crystal Structures 2020, 235(2), 483–484. https://doi.org/10.1515/NCRS-2019-0781

Somaya A. Abdel-Rahman, Ashraf K. El-Damasy, Ghada S. Hassan, Emad I. Wafa, Sean M. Geary, Azza R. Maarouf, and Aliasger K. Salem.  Cyclohepta [b]thiophenes as Potential Antiproliferative Agents: Design, Synthesis, In Vitro, and In Vivo Anticancer Evaluation. ACS Pharmacology & Translational Science 2020, 3(5), 965–977. https://doi.org/10.1021/ACSPTSCI.0C00096

Alaa S. Abdelrazeq, Hazem A. Ghabbour, Ali A. El-Emam, Doaa A. Osman, and Santiago Garcia-Granda. Synthesis and crystal structure of 3-(adamantan-1-yl)-4-(2-bromo-4-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione Abdelrazeq Alaa S. Acta Crystallographica Section E: Crystallographic Communications 2020, 76(2), 162–166. https://doi.org/10.1107/S2056989020000092/XI2020ISUP2.HKL

Abduelmula R. Abduelkarem, Hanan S. Anbar, Seyed O. Zaraei, Aya A. Alfar, Omayma S. Al-Zoubi, Eveen G. Abdelkarem, and Mohammed I. El-Gamal.  Diarylamides in anticancer drug discovery: A review of pre-clinical and clinical investigations. European Journal of Medicinal Chemistry 2020, 188. https://doi.org/10.1016/J.EJMECH.2019.112029

Hanan A. Al-Ghulikah, Akilandeswari Gopalan, Laxmi P. S. Vahisan, Mohamed A. Khalaf, Hazem A. Ghabbour, Ali A. El-Emam, M. Judith Percino, and Subbiah Thamotharan. Insights into the weak Csp3–H···H–Csp3 mediated supramolecular architecture in ethyl 2-(5-bromopentanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, a probable selective COX-2 lead molecule: An integrated crystallographic and theoretical approac. Journal of Molecular Structure 2020, 1199. https://doi.org/10.1016/J.MOLSTRUC.2019.127019

Abdullah M. Al-Majid, Hussien M. Ghawas, Mohammad S. Islam, Saied M. Soliman, Fardous F. El-Senduny, Farid A. Badria, M. Ali, Mohammed R. Shaik, Hazem A. Ghabbour, and Assem Barakat.  Synthesis of spiroindolone analogue via three components reaction of olefin with isatin and sarcosine: Anti-proliferative activity and computational studies. Journal of Molecular Structure 2020, 1204, 127500. https://doi.org/10.1016/J.MOLSTRUC.2019.127500

Aamal A. Al-Mutairi, Monirah A. Al-Alshaikh, Hazem A. Ghabbour, Edward R. T. Tiekink, and Ali A. El-Emam.  Crystal structure of 1-(adamantan-1-yl)-3-aminothiourea, C11H19N3S. Zeitschrift Fur Kristallographie - New Crystal Structures 2020, 235(5), 1115–1117. https://www.degruyter.com/document/doi/10.1515/ncrs-2020-0195/html?lang=en

Aamal A. Al-Mutairi, Bhavana K. P. Katari, Yatindrapravanan Narasimhan, Olivier Blacque, Lamya H. Al-Wahaibi, Monirah A. Al-Alshaikh, Ali A. El-Emam, M. Judith Percino, and Subbiah Thamotharan.  Interplay of weak intermolecular interactions in two Schiff’s bases with organic fluorine derived from 5-nitrothiophene-2-carboxaldehyde: Crystal structures, DFT calculation and in vitro evaluation of bioactivities. Journal of Molecular Structure 2020, 1221, 128883. https://doi.org/10.1016/J.MOLSTRUC.2020.128883

Fatmah A. M. Al-Omary, Nikhila C. Gude, Lamees S. Al-Rasheed, Hamad N. Alkahtani, Hanan M. Hassan, Ebtehal S. Al-Abdullah, Ali A. El-Emam, M. Judith Percino, and Subbiah Thamotharan.  X-ray and theoretical investigation of (Z)-3-(adamantan-1-yl)-1-(phenyl or 3-chlorophenyl)-S-(4-bromobenzyl) isothioureas: an exploration involving weak non-covalent interactions, chemotherapeutic activities and QM/MM binding energy. Journal of Biomolecular Structure and Dynamics 2020, https://doi.org/10.1080/07391102.2020.1840443

Mohyeddine Al-Qubati, Hazem A. Ghabbour, Saied M. Soliman, Abdullah M. Al-Majid, Assem Barakat, and Mujeeb A. Sultan.  Synthesis of N-(Anthracen-9-ylmethyl)-N-methyl-2-(phenylsulfonyl)ethanamine via Microwave Green Synthesis Method: X-ray Characterization, DFT and Hirshfeld Analysis. Crystals 2020, 10(8), 643. https://doi.org/10.3390/CRYST10080643

Sara T. Al-Rashood, Shymaa S. Elshahawy, Asmaa M. El-Qaias, Dina S. El-Behedy, Alshaimaa A. Hassanin, Selwan M. El-Sayed, Shahenda M. El-Messery, Moataz A. Shaldam, and Ghada S. Hassan.  New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study. Bioorganic & Medicinal Chemistry Letters 2020, 30(23). https://doi.org/10.1016/J.BMCL.2020.127611

Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, and Wagdy M. Eldehna. Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 831–839. https://doi.org/10.1080/14756366.2020.1743281

Lamya H. Al-Wahaibi, Natalia Alvarez, Olivier Blacque, Nicolás Veiga, Aamal A. Al-Mutairi, and Ali A. El-Emam.  Synthesis and Structure Insights of Two Novel Broad-Spectrum Antibacterial Candidates Based on (E)-N′-[(Heteroaryl)methylene] adamantane-1-carbohydrazides. Molecules 2020, 25(8), 1934. https://doi.org/10.3390/MOLECULES25081934

Lamya H. Al-Wahaibi, Kushumita Chakraborty, Nora H. Al-Shaalan, Mohamed Y. A. Syed Majeed, Olivier Blacque, Aamal A. Al-Mutairi, Ali A. El-Emam, M. Judith Percino, and Subbiah Thamotharan.  Quantitative analysis of hydrogen and chalcogen bonds in two pyrimidine-5-carbonitrile derivatives, potential DHFR inhibitors: an integrated crystallographic and theoretical study. RSC Advances 2020, 10(60), 36806–36817. https://doi.org/10.1039/D0RA07215J

Alaa S Abdelrazeq, Hazem A Ghabbour, Ali A El-Emam, Doaa A. Osman, Santiago Garcia-Granda.  Synthesis and crystal structure of 3-(adamantan-1- yl)-4-(2-bromo-4-fluorophenyl)-1H-1,2,4-triazole_5(4H)-thione. Acta Crystallographica Section E: Crystallographic Communications 2020, 76(2), 162–166. https://doi.org/10.1107/S2056989020000092

Hamad M. Alkahtani, Ashraf N. Abdalla, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman A. Almehizia, Mashael G. Alanazi, Ahmed Y. Ahmed, Osama I. Alwassil, Hany W. Darwish, Alaa A. M. Abdel-Aziz, and Adel S. El-Azab.  Synthesis, cytotoxic evaluation, and molecular docking studies of novel quinazoline derivatives with benzenesulfonamide and anilide tails: Dual inhibitors of EGFR/HER2. Bioorganic Chemistry 2020, 95. https://doi.org/10.1016/J.BIOORG.2019.103461

Abdulsalam A. M. Alkhaldi, Mohammad M. Al-Sanea, Alessio Nocentini, Wagdy M. Eldehna, Zainab M. Elsayed, Alessandro Bonardi, Mahmoud F. Abo-Ashour, Ashraf K. El-Damasy, Mohammed S. Abdel-Maksoud, Tarfah Al-Warhi, Paola Gratteri, Hatem A. Abdel-Aziz, Claudiu T. Supuran, and Radwan El-Haggar.  3-Methylthiazolo[3,2-a] benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies. European Journal of Medicinal Chemistry 2020, 207, 112745. https://doi.org/10.1016/J.EJMECH.2020.112745

Mezna S. Altowyan, M. Ali, Saied M. Soliman, Abdullah M. Al-Majid, Mohammad S. Islam, Sammer Yousuf, M. Iqbal Choudhary, Hazem A. Ghabbour, and Assem Barakat.  Synthesis, computational studies and biological activity of oxamohydrazide derivatives bearing isatin and ferrocene scaffolds. Journal of Molecular Structure 2020, 1202, 127372. https://doi.org/10.1016/J.MOLSTRUC.2019.127372

Hanan S. Anbar, Mohammed I. El-Gamal, Hamadeh Tarazi, Bong S. Lee, Hong R. Jeon, Dow Kwon, and Chang H. Oh. Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 1712–1726. https://doi.org/10.1080/14756366.2020.1819260

Hanan S. Anbar, Randa El-Gamal, Saif Ullah, Seyed O. Zaraei, Mariya Al-Rashida, Sumera Zaib, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, and Mohammed I. El-Gamal.  Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents. Bioorganic Chemistry 2020, 104. https://doi.org/10.1016/J.BIOORG.2020.104305

Ahmed T. A. Boraei, Hazem A. Ghabbour, Ahmed A. M. Sarhan, and Assem Barakat.  Expeditious Green Synthesis of Novel 4-Methyl-1,2,5,6-tetraazafluoranthen-3(2 H)-one Analogue from Ninhydrin: N/S-Alkylation and Aza-Michael Addition. ACS Omega, 5(10),5436–5442. https://doi.org/10.1021/acsomega.0c00045

Christopher Pigge, Moustafa T. Gabr.  Dinuclear platinum (ii) compounds and methods of use thereof (Patent No. US-2020308208-A1), 2020. https://pubchem.ncbi.nlm.nih.gov/patent/US-2020308208-A1

Adel S. El-Azab, Alaa A. M. Abdel-Aziz, Hany E. A. Ahmed, Sivia Bua, Alessio Nocentini, Nawaf A. AlSaif, Ahmad J. Obaidullah, Mohamed M. Hefnawy, and Claudiu T. Supuran.  Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 598–609. https://pubmed.ncbi.nlm.nih.gov/32009479/

Adel S. El-Azab, Alaa A. M. Abdel-Aziz, Nawaf A. AlSaif, Hamad M. Alkahtani, Mohammed M. Alanazi, Ahmad J. Obaidullah, Razan O. Eskandrani, and Amal Alharbi.  Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorganic Chemistry 2020, 104. https://doi.org/10.1016/J.BIOORG.2020.104345

Adel S. El-Azab, Alaa A. M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Hany E. A. Ahmed, and Claudiu T. Supuran.  S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 733–743. https://doi.org/10.1080/14756366.2020.1742117

Adel S. El-Azab, Hazem A. Ghabbour, Alaa A. M. Abdel-Aziz, and Hamad M. Alkahtani. Crystal structure of 6-iodo-3-phenyl-2-propylquinazolin-4(3H)-one, C17H15IN2O. Zeitschrift Fur Kristallographie - New Crystal Structures 2020, 235(2), 489–491. https://doi.org/10.1515/NCRS-2019-0788

Ashraf K. El-Damasy, Md M. Haque, Jung W. Park, Sang C. Shin, Jun S. Lee, Eunice E. Kim, and Gyochang Keum.  2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAF V600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. European Journal of Medicinal Chemistry 2020, 208, 112756. https://doi.org/10.1016/J.EJMECH.2020.112756

Ashraf K. El-Damasy, Heewon Jin, Seon H. Seo, Eun K. Bang, and Gyochang Keum.  Design, synthesis, and biological evaluations of novel 3-amino-4-ethynyl indazole derivatives as Bcr-Abl kinase inhibitors with potent cellular antileukemic activity. European Journal of Medicinal Chemistry 2020, 207, 112710. https://doi.org/10.1016/J.EJMECH.2020.112710

Ali A. El-Emam, Elangovan S. Kumar, Krishnakumar Janani, Lamya H. Al-Wahaibi, Olivier Blacque, Mohamed I. El-Awady, Nora H. Al-Shaalan, M. Judith Percino, and Subbiah Thamotharan.  Quantitative assessment of the nature of noncovalent interactions in N-substituted-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amines: insights from crystallographic and QTAIM analysis. RSC Advances 2020, 10(17), 9840–9853. https://doi.org/10.1039/D0RA00733A

Mohammed I. El-Gamal, Hany A. Omar, Mohammad H. Semreen, Israa A. Younes, Youmna Y. Zaghloul, Ayat E. Abbas, Iman G. Moussa, Fatima Hersi, and Chang H. Oh.  Antiproliferative activity of cycloalkanecarboxamide derivatives possessing sulfonate or sulfamate moiety. Bioorganic Chemistry 2020, 97. https://doi.org/10.1016/J.BIOORG.2020.103677

Mohammed I. El-Gamal, Seyed O. Zaraei, Paul A. Foster, Hanan S. Anbar, Randa El-Gamal, Raafat El-Awady, and Barry V. L. Potter.  A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation. Bioorganic & Medicinal Chemistry 2020, 28(8), 115406. https://doi.org/10.1016/J.BMC.2020.115406

Walaa M. El-Husseiny, Magda A. A. El-Sayed, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi, and Alaa A. M. Abdel-Aziz.  Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 744–758. https://doi.org/10.1080/14756366.2020.1740695

Mardia T. El Sayed, Alaadin E. Sarhan, Entsar Ahmed, Reham R. Khattab, Mohamed Elnaggar, Shahenda M. El-Messery, Moataz A. Shaldam, and Ghada S. Hassan.  Novel Pyruvate Kinase (PK) Inhibitors: New Target to Overcome Bacterial Resistance. ChemistrySelect 2020, 5(11), 3445–3453. https://doi.org/10.1002/SLCT.202000043

Mardia T. El Sayed, Sara N. Shabaan, Alaadin E. Sarhan, Shahenda M. El-Messery, Selwan M. El-Sayed, and Ghada S. Hassan.  DNA binding studies of novel diazatruxenones analogs as potential anticancer agents: Synthesis, antitumor investigation, DNA binding, SAR and molecular modeling calculation. Bioorganic Chemistry 2020, 104, 104323. https://doi.org/10.1016/J.BIOORG.2020.104323

Wagdy M. Eldehna, Ghada S. Hassan, Sara T. Al-Rashood, Hamad M. Alkahtani, Abdulrahman A. Almehizia, and Ghada H. Al-Ansary.  Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation. Marine Drugs 2020, 18(4). https://doi.org/10.3390/MD18040190

Ahmed Elkamhawy, Nam Y. Kim, Ahmed H. E. Hassan, Jung E. Park, Sora Paik, Jeong E. Yang, Kwang S. Oh, Byung H. Lee, Mi Y. Lee, Kye J. Shin, Ae N. Pae, Kyung T. Lee, and Eun J. Roh.  Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. European Journal of Medicinal Chemistry 2020, 188. https://doi.org/10.1016/J.EJMECH.2019.111955

Ahmed K. Farag, Ahmed H. E. Hassan, Byung S. Ahn, Ki D. Park, and Eun J. Roh.  Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 311–324. https://doi.org/10.1080/14756366.2019.1699554

Ahmed K. Farag, Ahmed H. E. Hassan, Kyung S. Chung, Jeong H. Lee, Hyo S. Gil, Kyung T. Lee, and Eun J. Roh.  Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approaches. Bioorganic Chemistry 2020, 103. https://doi.org/10.1016/J.BIOORG.2020.104121

Moustafa T. Gabr, and Natarajan A. Murugan.  Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands. Bioorganic & Medicinal Chemistry Letters 2020, 30(17). https://doi.org/10.1016/J.BMCL.2020.127370

Moustafa T. Gabr, Ashfaq U. Rehman, and Hai F. Chen.  Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling. ACS Medicinal Chemistry Letters 2020, 11(9), 1759–1765. https://doi.org/10.1021/ACSMEDCHEMLETT.0C00330

Moustafa T. Gabr, and Katarzyna Świderek.  Discovery of a Histidine-Based Scaffold as an Inhibitor of Gut Microbial Choline Trimethylamine-Lyase. ChemMedChem 2020, 15(23), 2273–2279. https://doi.org/10.1002/CMDC.202000571

Moustafa T. Gabr, Anand Balupuri, and Nam S. Kang.  High-Throughput Platform for Real-Time Monitoring of ATP-Generating Enzymes in Living Cells Based on a Lanthanide Probe. ACS Sensors 2020, 5(7), 1872–1876. https://doi.org/10.1021/ACSSENSORS.0C00897

Moustafa T. Gabr, and Florent Barbault.  First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases. Chemical Communications 2020, 56(67), 9695–9698. https://doi.org/10.1039/D0CC04249H

Moustafa T. Gabr, and Simone Brogi. MicroRNA-Based Multitarget Approach for Alzheimer’s Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis. Journal of Medicinal Chemistry 2020, 63(17), 9695–9704. https://doi.org/10.1021/ACS.JMEDCHEM.0C00756

Moustafa T. Gabr, Sefa Celik, Sevim Akyuz, and Aysen E. Ozel.  Biological evaluation and pharmacokinetic profiling of a coumarin-benzothiazole hybrid as a new scaffold for human gliomas. Medicine in Drug Discovery 2020, 7, 100012. https://doi.org/10.1016/J.MEDIDD.2020.100012

Moustafa T. Gabr, and Sanjiv S. Gambhir.  Discovery and Optimization of Small-Molecule Ligands for V-Domain Ig Suppressor of T-Cell Activation (VISTA). Journal of the American Chemical Society 2020, 142(38), 16194–16198. https://doi.org/10.1021/JACS.0C07276

Moustafa T. Gabr, Tom Haywood, Gayatri Gowrishankar, Ananth Srinivasan, and Sanjiv S. Gambhir.  New synthesis of 6″-[18 F]fluoromaltotriose for positron emission tomography imaging of bacterial infection. Journal of Labelled Compounds & Radiopharmaceuticals 2020, 63(11), 466–475. https://doi.org/10.1002/JLCR.3868

Moustafa T. Gabr, David MacHalz, Szymon Pach, and Gerhard Wolber. A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota. RSC Medicinal Chemistry 2020, 11(12), 1402–1412. https://doi.org/10.1039/D0MD00218F

Moustafa T. Gabr., and Francesca Peccati.  Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration. ACS Chemical Neuroscience 2020, 11(14), 2051–2057. https://doi.org/10.1021/ACSCHEMNEURO.0C00281

Moustafa T. Gabr & F. Christopher Pigge.  AIE Luminogens as Versatile Bioprobes. Current Analytical Chemistry 2020, 17(3), 302–316. https://doi.org/10.2174/1573411016666200110153737

Mahmoud M. Gamal El-Din, Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Huijeong Lee, Jungseung Choi, Tae W. Kim, Ji S. Shin, Hwi H. Lee, Hee K. Kim, Kyung T. Lee, and Daejin Baek.  Inhibitory effects of triarylpyrazole derivatives on LPS-induced nitric oxide and PGE 2 productions in murine RAW 264.7 macrophages. Bioorganic & Medicinal Chemistry Letters 2020, 30(4). https://doi.org/10.1016/J.BMCL.2019.126884

Gyo C. Keum, Ashraf K. El-Damasy, Hee W. Jin, KANG Taek, Eun K. Bang. Novel indazole derivatives and pharmaceutical composition for preventing, improving or treating cancer containing the same-Patent KR-20200142245-A-PubChem (Patent No. US20200392127A1), 2020. https://pubchem.ncbi.nlm.nih.gov/patent/KR-20200142245-A

Ahmed H. E. Hassan. Kyung T. Lee, and Yong S. Lee.  Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations. European Journal of Medicinal Chemistry 2020, 187. https://doi.org/10.1016/J.EJMECH.2019.111965

Ahmed H. E. Hassan, Kyung T. Park, Hye J. Kim, Hyo J. Lee, Yeong H. Kwon, Ji Y. Hwang, Choon G. Jang, Jin H. Chung, Ki D. Park, Sang J. Lee, Seung J. Oh, and Yong S. Lee.  Fluorinated CRA13 analogues: Synthesis, in vitro evaluation, radiosynthesis, in silico and in vivo PET study. Bioorganic Chemistry 2020, 99. https://doi.org/10.1016/J.BIOORG.2020.103834

Khalid Karrouchi, Saad Fettach, Mukesh M. Jotani, Abir Sagaama, Smaail Radi, Hazem A. Ghabbour, Yahia N. Mabkhot, Benacer Himmi, My E. Faouzi, and Noureddine Issaoui.  Synthesis, crystal structure, hirshfeld surface analysis, DFT calculations, anti-diabetic activity and molecular docking studies of (E)-N’-(5-bromo-2-hydroxybenzylidene) isonicotinohydrazide. Journal of Molecular Structure 2020, 1221, 128800. https://doi.org/10.1016/J.MOLSTRUC.2020.128800

Jeong H. Lee, Hwi H. Lee, Ki D. Ryu, Misong Kim, Dohyeong Ko, Kyung S. Chung, Ahmed H. E. Hassan, Seung H. Lee, Jae Y. Lee, and Kyung T. Lee.  KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. Journal of Clinical Medicine 2020, 9(3). https://doi.org/10.3390/JCM9030704

Yahia N. Mabkhot, Jamal M. A. Khaled, Mujeeb A. S. Sultan, Naiyf S. H. A. Alharbi, Hazem A. Ghabbour, Fahd A. Nasr, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Hamed Algarni, and Yahya I. Asiri.  Synthesis, X-Ray Structural Analysis and Computational Studies of a Novel Bis(2-Thienyl) Disulfide Derivative.
Polycyclic Aromatic Compounds 2020,  https://doi.org/10.1080/10406638.2020.1852281

Yahia N. Mabkhot, Jamal M. A. Khaled, Mujeeb A. S. Sultan, Naiyf S. H. A. Alharbi, Hazem A. Ghabbour, Fahd A. Nasr, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Hamed Algarni, and Yahya I. Asiri.   Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent. Medicinal Chemistry Research 2020, 29(6), 954–961. https://doi.org/10.1007/S00044-020-02535-2/FIGURES/7

Maramai, Samuele, Mohamed Benchekroun, Moustafa T. Gabr, and Samir Yahiaoui. Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations. BioMed Research International 2020, 14(3), 437. https://doi.org/10.1155/2020/5120230

Mamdouh F. A. Mohamed, Adel A. Marzouk, Ayman Nafady, Dalia A. El-Gamal, Rasha M. Allam, Gamal El Din A. Abuo-Rahma, Hussein I. El Subbagh, and Amr H. Moustafa.  Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors. Bioorganic Chemistry 2020, 105. https://doi.org/10.1016/J.BIOORG.2020.104439

Amal M. Mokhtar, Shahenda M. El-Messery, Mariam A. Ghaly, and Ghada S. Hassan.  Targeting EGFR tyrosine kinase: Synthesis, in vitro antitumor evaluation, and molecular modeling studies of benzothiazole-based derivatives. Bioorganic Chemistry 2020, 104. https://doi.org/10.1016/J.BIOORG.2020.104259

Moustafa T Gabr, Samir Yahiaoui.  Multitarget Therapeutics for Neurodegenerative Diseases. BioMed Research International 2020, 2020. https://www.hindawi.com/journals/bmri/si/914694/

Abdullatif Bin Muhsinah, Abdulrhman Alsayari, H. Algarni, Saied M. Soliman, Nabila A. Kheder, Hazem A. Ghabbour, Yahya I. Asiri, Kumar Venkatesan, and Yahia N. Mabkhot.  Synthesis, X-ray analysis and computational studies of two novel thiophene derivatives. Journal of Sulfur Chemistry 2020, 41(5), 517–529. https://doi.org/10.1080/17415993.2020.1769096

Nermeen A. Qandeel, Ashraf K. El-Damasy, Maha H. Sharawy, Said M. Bayomi, and Nadia S. El-Gohary.  Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives. Bioorganic Chemistry 2020, 102. https://doi.org/10.1016/J.BIOORG.2020.103890

Radwan, H. A. M., H. K. A. El-Mawgoud, F. El-Mariah, A. M. El-Agrody, A. E. Amr, M. A. Al-Omar, and Hazem A. Ghabbour.  Single-Crystal Structure and Antimicrobial Activity of Ethyl 3-Amino-1-(4-chlorophenyl)-9-hydroxy1H-benzo[f]chromene-2-carboxylate Combined with Ethyl α-Cyano-4-chlorocinnamate. Russian Journal of General Chemistry 2020, 90(2), 299–304. https://doi.org/10.1134/S107036322002022X/TABLES/5

Mennatallah A. Shaheen, Ali A. El-Emam, and Nadia S. El-Gohary. 1,4,5,6,7,8-Hexahydroquinolines and 5,6,7,8-tetrahydronaphthalenes: A new class of antitumor agents targeting the colchicine binding site of tubulin. Bioorganic Chemistry 2020, 99, 103831. https://doi.org/10.1016/J.BIOORG.2020.103831

Mennatallah A. Shaheen, Ali A. El-Emam, and Nadia S. El-Gohary. Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant EGFR (L858R and T790M). Bioorganic Chemistry 2020, 105. https://doi.org/10.1016/J.BIOORG.2020.104274

Sang C. Shin, Ashraf K. El-Damasy, Ju H. Lee, Seon H. Seo, Ji H. Kim, Young H. Seo, Yuri Lee, Ji H. Yu, Eun K. Bang, Eunice E. Kim, and Gyochang Keum.  Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90. International Journal of Molecular Sciences 2020, 21(24), 1–21. https://doi.org/10.3390/IJMS21249377

Maksim Shundalau, Yuliya L. Mindarava, Anna S. Matsukovich, Sergey V. Gaponenko, Ali A. El-Emam, and Hamad N. Alkahtani.  Structural, vibrational and uv/vis studies of adamantane-containing triazole thiones by spectral, DFT and multi-reference ab initio methods. Zeitschrift Fur Physikalische Chemie 2020, 234(1), 85–106. https://doi.org/10.1007/s10812-018-0633-5

Isha Singh, Lamya H. Al-Wahaibi, Ruchi Srivastava, Onkar Prasad, Shilendra K. Pathak, Saurabh Kumar, Shama Parveen, Monisha Banerjee, Ali A. El-Emam, and Leena Sinha.  DFT Study on the Electronic Properties, Spectroscopic Profile, and Biological Activity of 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole with Anticancer Properties. ACS Omega 2020, 5(46), 30073–30087. https://doi.org/10.1021/ACSOMEGA.0C04474

Abdallah Turky, Ashraf H. Bayoumi, Adel Ghiaty, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, and Hamada S. Abulkhair.  Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorganic Chemistry 2020, 101. https://doi.org/10.1016/J.BIOORG.2020.104019

Saif Ullah, Mohammed I. El-Gamal, Sumera Zaib, Hanan S. Anbar, Seyed O. Zaraei, Rawan M. Sbenati, Julie Pelletier, Jean Sévigny, Chang H. Oh, and Jamshed Iqbal.  Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase. Bioorganic Chemistry 2020, 99. https://doi.org/10.1016/J.BIOORG.2020.103783

Eman T. Warda, Ihsan A. Shehata, Mahmoud B. El-Ashmawy, and Nadia S. El-Gohary.  New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation. Bioorganic & Medicinal Chemistry 2020, 28(21). https://doi.org/10.1016/J.BMC.2020.115674

Mirwais Wardak, Gayatri Gowrishankar, Xin Zhao, Yonggang Liu, Edwin Chang, Mohammad Namavari, Tom Haywood, Moustafa T. Gabr, Evgenios Neofytou, Tony Chour, Xulei Qin, José G. Vilches-Moure, Jonathan Hardy, Christopher H. Contag, Michael V. McConnell, Joseph C. Wu, and Sanjiv S. Gambhir.  Molecular Imaging of Infective Endocarditis With 6’’-[ 18 F] Fluoromaltotriose Positron Emission Tomography-Computed Tomography. Circulation 2020, 141(21), 1729–1731. https://doi.org/10.1161/CIRCULATIONAHA.119.043924

Dana M. Zaher, Mohammed I. El-Gamal, Hany A. Omar, Sarah N. Aljareh, Salma A. Al-Shamma, Aya J. Ali, Sumera Zaib, and Jamshed Iqbal.  Recent advances with alkaline phosphatase isoenzymes and their inhibitors. Archiv Der Pharmazie 2020, 353(5). https://doi.org/10.1002/ARDP.202000011