Amal A. El-Masry, Mohammed E. A. Hammouda, Dalia R. El-Wasseef, and Saadia M. El-Ashry.  Eco-Friendly Green Liquid Chromatographic Determination of Azelastine in the Presence of its Degradation Products: Applications to Degradation Kinetics. Journal of AOAC INTERNATIONAL 2019, 102(1), 81–90. https://doi.org/10.5740/JAOACINT.17-0472

Heba Elmansi, Jenny J. Nasr, Azza H. Rageh, Mohamed I. El-Awady, Ghada S. Hassan, Hatem A. Abdel-Aziz, and Fathalla Belal.  Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC. BMC Chemistry 2019, 13(1), 1–7. https://doi.org/10.1186/S13065-019-0607-6/FIGURES/3

Yomna A. Salem, Mohammed E. A. Hammouda, Mohamed A. Abu El-Enin, and Saadia M. El-Ashry.  Application of derivative emission fluorescence spectroscopy for determination of ibuprofen and phenylephrine simultaneously in tablets and biological fluids. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 2019, 210, 387–397. https://doi.org/10.1016/J.SAA.2018.11.054

Yomna A. Salem, Mohammed E. A. Hammouda, Mohamed A. Abu El-Enin, and Saadia M. El-Ashry.  Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler. BMC Chemistry 2019, 13(1). https://doi.org/10.1186/S13065-019-0592-9

Abd El-Galil E. Amr, Mohamed A. Al-Omar, Hazem A. Ghabbour.  Beta-adrenergic blocking compound (Patent No. US20190352329A1). 2019, https://patents.google.com/patent/US20190352329A1/en

Alaa A. M. Abdel-Aziz, Andrea Angeli, Adel S. El-Azab, Mohammed E. A. Hammouda, Magda A. El-Sherbeny, and Claudiu T. Supuran.  Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions. Bioorganic Chemistry 2019, 84, 260–268. https://doi.org/10.1016/J.BIOORG.2018.11.033

Alaa A. M. Abdel-Aziz, Adel S. El-Azab, Silvia Bua, Alessio Nocentini, Mohamed A. Abu El-Enin, Mohammed M. Alanazi, Nawaf A. AlSaif, Mohamed M. Hefnawy, and Claudiu T. Supuran.  Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives. Bioorganic Chemistry 2019, 87, 425–431. https://doi.org/10.1016/J.BIOORG.2019.03.052

Alaa A. M. Abdel-Aziz, Adel S. El-Azab, Adel H. Ghiaty, Paola Gratteri, Claudiu T. Supuran, and Alessio Nocentini.  4-Substituted benzenesulfonamides featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition. Bioorganic Chemistry 2019, 83, 198–204. https://doi.org/10.1016/J.BIOORG.2018.10.037

Maged S. Abdel-Kader, Khalid S. Al Shahrani, Mohammed H. Alqarni, Mohammed A. Salkini, Elsadig H. Khamis, Hazem A. Ghabbour, and Saleh I. Alqasoumi.  Effect of hydroxylated solvents on the active constituents of Salvadora persica root “Siwak.” Saudi Pharmaceutical Journal 2019, 27(2), 220–224. https://doi.org/10.1016/J.JSPS.2018.11.001

Mohammed S. Abdel-Maksoud, Usama M. Ammar, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, Karim I. Mersal, Eslam M. H. Ali, Kyung H. Yoo, Kyung T. Lee, and Chang H. Oh.  Design, synthesis, and anticancer activity of imidazo[2,1-b] oxazole-based RAF kinase inhibitors. Bioorganic Chemistry 2019, 93. https://doi.org/10.1016/J.BIOORG.2019.103349

Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Dalia R. Benhalilou, Sandy Ashraf, Shatha A. Mohammed, and Chang H. Oh.  Mechanistic/mammalian target of rapamycin: Recent pathological aspects and inhibitors. Medicinal Research Reviews 2019, 39(2), 631–664. https://doi.org/10.1002/MED.21535

Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, and Chang H. Oh.  Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 2019, 34(1), 97–109. https://doi.org/10.1080/14756366.2018.1530225

Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Silvia Bua, Sara T. Al-Rashood, Ghada S. Hassan, Alessandro Bonardi, Abdulrahman A. Almehizia, Hamad M. Alkahtani, Amal Alharbi, Paola Gratteri, and Claudiu T. Supuran.  Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights. International Journal of Molecular Sciences 2019, 20(10). https://doi.org/10.3390/IJMS20102484

Entesar M. Ahmed, Alaadin E. Sarhan, Dina H. El-Naggar, Reham R. Khattab, Mohamed El-Naggar, Shahenda M. El-Messery, Ghada S. Hassan, Marwa M. Mounier, Khaled Mahmoud, Neama I. Ali, Karima F. Mahrous, Mamdouh M. Ali, and Mardia T. El Sayed.  Towards breast cancer targeting: Synthesis of tetrahydroindolocarbazoles, antibreast cancer evaluation, uPA inhibition, molecular genetic and molecular modelling studies. Bioorganic Chemistry 2019, 93. https://doi.org/10.1016/J.BIOORG.2019.103332

Hanan A. Al-Ghulikah, Hazem A. Ghabbour, Edward R. T. Tiekink, and Ali A. El-Emam.  Crystal structure of 4-bromobenzyl (Z)-N-(adamantan-1-yl)morpholine-4-carbothioimidate, C 22 H 29 BrN 2 OS. Zeitschrift Fur Kristallographie - New Crystal Structures, 234(5), 1001–1003. https://doi.org/10.1515/ncrs-2019-0216

Hanan A. Al-Ghulikah., Darya Meniailava, Ulada Vysotskaya, Anna Matsukovich, Ali A. El-Emam, and Maksim Shundalau.  Spectral and quantum chemical analysis of ethyl 4-[3-(adamantan-1-yl)-4-phenyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazole-1-yl]methylpiperazine-1-carboxylate. Journal of Theoretical and Computational Chemistry 2019, 18(6), 1950029. https://doi.org/10.1142/S0219633619500299

Aamal A. Al-Mutairi, Monirah A. Al-Alshaikh, Fatmah A. M. Al-Omary, Hanan M. Hassan, Areej M. El-Mahdy, and Ali A. El-Emam.  Synthesis, Antimicrobial, and Anti-Proliferative Activities of Novel 4-(Adamantan-1-yl)-1-arylidene-3-thiosemicarbazides, 4-Arylmethyl N′-(Adamantan-1-yl)piperidine-1-carbothioimidates, and Related Derivatives. Molecules 2019, 24(23), 4308. https://doi.org/10.3390/MOLECULES24234308

Huda S. Al-Salem, Tebyan O. Mirgany, Fadhilah Al-Enizy, Amany Z. Mahmoud, Hussein I. El-Subbagh, Mohamed A. Al-Omar, and Ahmed M. Naglah.  Synthesis and Antimicrobial Testing of some Quinazolinone Compounds. Latin American Journal of Pharmacy 2019, 38(6), 1194–1201.

Reem I. Al-Wabli, Alwah R. Al-Ghamdi, S. V. Aswathy, Hazem A. Ghabbour, Mohamed H. Al-Agamy, I. Hubert Joe, and Mohamed I. Attia. (2019a). (2E)-2-[1-(1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl) propylidene]-N-(2-chlorophenyl) hydrazine carboxamide: Synthesis, X-ray structure, hirshfeld surface analysis, DFT calculations, molecular docking and antifungal profile. Crystals 2019, 9(2), 82–96. https://doi.org/10.3390/CRYST9020082

Reem I. Al-Wabli, Alwah R. Al-Ghamdi, Suchindra Amma V. Aswathy, Hazem A. Ghabbour, Mohamed H. Al-Agamy, Issac H. Joe, and Mohamed I. Attia. (2019b). Synthesis, Single Crystal X-ray Structure, DFT Computations, Hirshfeld Surface Analysis and Molecular Docking Simulations on ({[(1E)-1-(1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propylidene]amino}oxy)(furan-2-yl)methanone: A New Antifungal Agent. Crystals 2019, 9(1), 25. https://doi.org/10.3390/CRYST9010025

Reem I. Al-Wabli, Alwah R. Al-Ghamdi, Hazem A. Ghabbour, Mohamed H. Al-Agamy, and Mohamed I. Attia. (2019a). Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities. Drug Design, Development and Therapy 2019, 13, 775. https://doi.org/10.2147/DDDT.S199135

Reem I. Al-Wabli, Alwah R. Al-Ghamdi, Hazem A. Ghabbour, Mohamed H. Al-Agamy, and Mohamed I. Attia. (2019b). Synthesis and Spectroscopic Identification of Certain Imidazole-Semicarbazone Conjugates Bearing Benzodioxole Moieties: New Antifungal Agents. Molecules 2019, 24(1), 200. https://doi.org/10.3390/MOLECULES24010200

Lamya H. Al-Wahaibi, Gopalan Akilandeswari, Ravisankar Anusha, Nora H. Al-Shaalan, Omkulthom M. Alkmali, Ali A. El-Emam, Judith M. Percino, and Subbiah Thamotharan.  Insights into the nature of weak noncovalent interactions in 3-(4-fluorophenyl)-6-(2-fluorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole, a potential bioactive agent: X-ray, QTAIM and molecular docking analysis. Journal of Molecular Structure 2019, 1183, 331–341. https://doi.org/10.1016/J.MOLSTRUC.2019.01.106

Lamya H. Al-Wahaibi, Nora H. Al-Shaalan, Hazem A. Ghabbour, Edward R. T. Tiekink, and Ali A. El-Emam.  Crystal structure of 3,5-bis(trifluoromethyl)benzyl (Z)-N′-(adamantan-1-yl)-4-phenylpiperazine-1-carbothioimidate, C30H33F6N3S. Zeitschrift Fur Kristallographie - New Crystal Structures 2019, 234(5), 1009–1012. https://doi.org/10.1515/ncrs-2019-0220

Lamya H. Al-Wahaibi, Jacques Joubert, Olivier Blacque, Nora H. Al-Shaalan, and Ali A. El-Emam. Crystal structure, Hirshfeld surface analysis and DFT studies of 5-(adamantan-1-yl)-3-[(4-chlorobenzyl) sulfanyl]-4-methyl-4H-1,2,4-triazole, a potential 11β-HSD1 inhibitor. Scientific Reports 2019, 9(1), 1–11. https://doi.org/10.1038/s41598-019-56331-z

Lamya H. Al-Wahaibi, Nandakumar S. Kumar, Ali A. El-Emam, Natarajan S. Venkataramanan, Hazem A. Ghabbour, Abdul Malek S. Al-Tamimi, Judith Percino, and Subbiah Thamotharan. (2019a). Investigation of potential anti-malarial lead candidate 2-(4-fluorobenzylthio)-5-(5-bromothiophen-2-yl)-1,3,4-oxadiazole: Insights from crystal structure, DFT, QTAIM and hybrid QM/MM binding energy analysis. Journal of Molecular Structure 2019, 1175, 230–240. https://doi.org/10.1016/J.MOLSTRUC.2018.07.102

Lamya H. Al-Wahaibi, Y. Sert, F. Ucun, Nora H. Al-Shaalan, A. Alsfouk, Ali. A. El-Emam, and Mustafa Karakaya.  Theoretical and experimental spectroscopic studies, XPS analysis, dimer interaction energies and molecular docking study of 5-(adamantan-1-yl)-N-methyl-1,3,4-thiadiazol-2-amine. Journal of Physics and Chemistry of Solids 2019, 135, 109091. https://doi.org/10.1016/J.JPCS.2019.109091

Md M. Alam, Ahmed H. E. Hassan, Kun W. Lee, Min C. Cho, Ji S. Yang, Jiho Song, Kyung H. Min, Jongki Hong, Dong H. Kim, and Yong S. Lee.  Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids. Bioorganic Chemistry 2019, 84, 51–62. https://doi.org/10.1016/J.BIOORG.2018.11.021

Hamad M. Alkahtani, Mohammed M. Alanazi, Fadilah S. Aleanizy, Fulwah Y. Alqahtani, Ali Alhoshani, Fawaz E. Alanazi, Abdulrahman A. Almehizia, Ashraf N. Abdalla, Mashael G. Alanazi, Adel S. El-Azab, and Alaa A. M. Abdel-Aziz.  Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies. Saudi Pharmaceutical Journal 2019, 27(5), 682–693. https://doi.org/10.1016/J.JSPS.2019.04.003

Zainab Almarhoon, Kholood A. Dahlous, Rakia Abd Alhameed, Hazem A. Ghabbour, Ayman El-Faham.  A Simple, Efficient, and Eco-Friendly Method for the Preparation of 3-Substituted-2,3-dihydroquinazolin-4(1H)-one Derivatives. Molecules 2019, 24(22), 4052. https://doi.org/10.3390/MOLECULES24224052

Zainab Almarhoon, Saied M. Soliman, Hazem A. Ghabbour, and Ayman El-Faham.  A Facile and Eco-Friendly Method for the Synthesis of Sulfonamide and Sulfonate Carboxylic Acid Derivatives—X-ray Structure, Hirshfeld Analysis and Spectroscopic Characterizations. Crystals 2019, 9(1), 35. https://doi.org/10.3390/CRYST9010035

Maha S. Almutairi, D. R. Leenaraj, Hazem A. Ghabbour, I. Hubert Joe, and Mohamed I. Attia.  Spectroscopic identification, structural features, Hirshfeld surface analysis and molecular docking studies on stiripentol: An orphan antiepileptic drug. Journal of Molecular Structure 2019, 1180, 110–118. https://doi.org/10.1016/J.MOLSTRUC.2018.11.088

Waad D. Alrohily, Mahmoud E. Habib, Shahenda M. El-Messery, Abdulmalik Alqurshi, Hussein I. El-Subbagh, and El Sayed E. Habib.  Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors. Microbial Pathogenesis 2019, 136, 103674. https://doi.org/10.1016/J.MICPATH.2019.103674

Mezna S. Altowyan, Saleh Atef, Mohamed H. Al-Agamy, Saied M. Soliman, M. Ali, Mohammed R. Shaik, M. Iqbal Choudhary, Hazem A. Ghabbour, and Assem Barakat.  Synthesis and characterization of a spiroindolone pyrothiazole analog via X-ray, biological, and computational studies. Journal of Molecular Structure 2019, 1186, 384–392. https://doi.org/10.1016/J.MOLSTRUC.2019.03.032

Mezna S. Altowyan, Assem Barakat, Abdullah M. Al-Majid, Hazem A. Ghabbour, Abdelkader Zarrouk, and Ismail Warad.  Vibrational spectral analysis, XRD-structure, computation, exoendo isomerization and non-linear optical crystal of 5 -(( 5-c hlo ro-1H -i ndo l-2 -yl )me thy len e)- 1,3 -di eth yl-2-t hio xod ihy-dropyrimidine-4,6 (1H,5H)-dione. BMC Chemistry 2019, 13(3), 1–14. https://doi.org/10.1186/S13065-019-0524-8/FIGURES/10

Mezna S. Altowyan, Assem Barakat, Saied M. Soliman, Abdullah M. Al-Majid, M. Ali, Yaseen A. M. M. Elshaier, and Hazem A. Ghabbour.  A new barbituric acid derivatives as reactive oxygen scavenger: Experimental and theoretical investigations. Journal of Molecular Structure 2019, 1175, 524–535. https://doi.org/10.1016/J.MOLSTRUC.2018.07.105

Abd El-Galil E. Amr, Mohamed F. El-Shehry, Alhussein A. Ibrahim, Hanaa M. Hosni, Mohamed A. Al-Omar, and Hazem A. Ghabbour.  Synthesis and Molecular Docking of New Thiophene Derivatives as Lactate Dehydrogenase-A Inhibitors. Mini-Reviews in Medicinal Chemistry 2019, 19(10), 833–841. https://doi.org/10.2174/1389557519666190212165302

Ashraf N. Abdalla, Mohamed E. Elzubier, Aslam Akhmed, Bader Ammar, Antonio Vassallo, Nunziatina D. Tommasi, Ahmed M. Gouda, Alkahtani Hamad, Alaa A. M. Abdel-Aziz, Adel S. El-Azab. A Novel Quinazoline Inhibits Hsp90 Protein, EGFR and Induces Apoptosis in Leukemia Cells. The 17th Annual Congress of International Drug Discovery Science and Technology, Kyoto, Japan, 391–391. 2019 https://www.researchgate.net/publication/341526516_A_Novel_Quinazoline_Inhibits_Hsp90_Protein_EGFR_and_Induces_Apoptosis_in_Leukemia_Cells

Marwa Ayman, Shahenda M. El-Messery, Elsayed E. Habib, Sara T. Al-Rashood, Abdulrahman A. Almehizia, Hamad, Ghada S. Hassan. Targeting microbial resistance: Synthesis, antibacterial evaluation, DNA binding and modeling study of new chalcone-based dithiocarbamate derivatives. Bioorganic Chemistry 2019, 85, 282–292. https://doi.org/10.1016/J.BIOORG.2019.01.001

Farid A. Badria, Saleh Atef, Abdullah M. Al-Majid, M. Ali, Yaseen A. M. M. Elshaier, Hazem A. Ghabbour, Mohammad S. Islam, and Assem Barakat.  Synthesis and Inhibitory Effect of Some Indole-Pyrimidine Based Hybrid Heterocycles on α-Glucosidase and α-Amylase as Potential Hypoglycemic Agents. ChemistryOpen 2019, 8(10), 1288–1297. https://doi.org/10.1002/OPEN.201900240

Farid A. Badria, Saied M. Soliman, Saleh Atef, Mohammad S. Islam, Abdullah M. Al-Majid, Necmi Dege, Hazem A. Ghabbour, M. Ali, Fardous F. El-Senduny, and Assem Barakat.  Anticancer Indole-Based Chalcones: A Structural and Theoretical Analysis. Molecules 2019, 24(20), 3728. https://doi.org/10.3390/MOLECULES24203728

Assem Barakat, Fardous F. El-Senduny, Zainab Almarhoon, Hessa H. Al-Rasheed, Farid A. Badria, Abdullah M. Al-Majid, Hazem A. Ghabbour, and Ayman El-Faham.  Synthesis, X-ray crystal structures, and preliminary antiproliferative activities of new s-triazine-hydroxybenzylidene hydrazone derivatives. Journal of Chemistry 2019, 2019, 9403908. https://doi.org/10.1155/2019/9403908

Assem Barakat, Mohammad S. Islam, Hussien M. Ghawas, Abdullah M. Al-Majid, Fardous F. El-Senduny, Farid A. Badria, Yaseen A. M. M. Elshaier, and Hazem A. Ghabbour.  Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction. Bioorganic Chemistry 2019, 86, 598–608. https://doi.org/10.1016/J.BIOORG.2019.01.053

Ahmed T. A. Boraei, Hazem A. Ghabbour, Mohamed S. Gomaa, El Sayed H. El Ashry, and Assem Barakat.  Synthesis and Anti-Proliferative Assessment of Triazolo-Thiadiazepine and Triazolo-Thiadiazine Scaffolds. Molecules 2019, 24(24), 4471. https://doi.org/10.3390/MOLECULES24244471

Adel S. El-Azab, Alaa A. M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Mohammed M. Alanazi, Nawaf A. AlSaif, Ibrahim A. Al-Suwaidan, Mohamed M. Hefnawy, and Claudiu T. Supuran.  Synthesis and comparative carbonic anhydrase inhibition of new Schiff’s bases incorporating benzenesulfonamide, methanesulfonamide, and methylsulfonylbenzene scaffolds. Bioorganic Chemistry 2019, 92. https://doi.org/10.1016/J.BIOORG.2019.103225

Adel S. El-Azab, Alaa A. M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Abdulrahman A. Almehizia, Mohammed M. Alanazi, Mohamed M. Hefnawy, and Claudiu T. Supuran.  New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment. European Journal of Medicinal Chemistry 2019, 181. https://doi.org/10.1016/J.EJMECH.2019.111573

Adel S. El-Azab, Alaa A. M. Abdel-Aziz, Sivia Bua, Alessio Nocentini, Manal A. El-Gendy, Menshawy A. Mohamed, Taghreed Z. Shawer, Nawaf A. AlSaif, and Claudiu T. Supuran..  Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors. Bioorganic Chemistry 2019, 87, 78–90. https://doi.org/10.1016/J.BIOORG.2019.03.007

Mohammed I. El-Gamal, Hanan S. Anbar, Hamadeh Tarazi, and Chang H. Oh.  Discovery of a potent p38α/MAPK14 kinase inhibitor: Synthesis, in vitro/in vivo biological evaluation, and docking studies. European Journal of Medicinal Chemistry 2019, 183. https://doi.org/10.1016/J.EJMECH.2019.111684

Mohammed I. El-Gamal, Saif Ullah, Seyed O. Zaraei, Saquib Jalil, Sumera Zaib, Dana M. Zaher, Hany A. Omar, Hanan S. Anbar, J. Pelletier, Jean Sévigny, and Jamshed Iqbal.  Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase. European Journal of Medicinal Chemistry 2019, 181. https://doi.org/10.1016/J.EJMECH.2019.07.063

Nadia S. El-Gohary, Moustafa T. Gabr, and Mona. I. Shaaban.  Synthesis, molecular modeling and biological evaluation of new pyrazolo[3,4-b] pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents. Bioorganic Chemistry 2019, 89, 102976. https://doi.org/10.1016/J.BIOORG.2019.102976

Nadia S. El-Gohary, Samia S. Hawas, Moustafa T. Gabr, Mona I. Shaaban, and Mahmoud. B. El-Ashmawy.  New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activities. Bioorganic Chemistry 2019, 92. https://doi.org/10.1016/J.BIOORG.2019.103109

Mohamed M. El-Kerdawy, Mariam A. Ghali, Sara A. Darwish, Hatem A. Abdel-Aziz, Ahmad R. Elsheakh, Rehab S. Abdelrahman, and Ghada S. Hassan.  New benzimidazothiazole derivatives as anti-inflammatory, antitumor active agents: Synthesis, in-vitro and in-vivo screening and molecular modeling studies. Bioorganic Chemistry 2019, 83, 250–261. https://doi.org/10.1016/J.BIOORG.2018.10.048

Marwa A. M. S. El-Sharief, Samir Y. Abbas, Ahmed M. S. El-Sharief, Nermien M. Sabry, Ziad Moussa, Shahenda M. El-Messery, Ahmed R. Elsheakh, Ghada S. Hassan, and Mardia T. El Sayed.  5-Thioxoimidazolidine-2-one derivatives: Synthesis, anti-inflammatory activity, analgesic activity, COX inhibition assay and molecular modelling study. Bioorganic Chemistry 2019, 87, 679–687. https://doi.org/10.1016/J.BIOORG.2019.03.075

Wagdy M. Eldehna, Mohamed A. Abdelrahman, Alessio Nocentini, Silvia Bua, Sara T. Al-Rashood, Ghada S. Hassan, Alessandro Bonardi, Abdulrahman A. Almehizia, Hamad M. Alkahtani, Amal Alharbi, Paola Gratteri, and Claudiu T. Supuran.  Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity. Bioorganic Chemistry 2019, 90, 103102. https://doi.org/10.1016/J.BIOORG.2019.103102

Wagdy M. Eldehna, Mahmoud F. Abo-Ashour, Emanuela Berrino, Daniela Vullo, Hazem A. Ghabbour, Sara T. Al-Rashood, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Hatem A. Abdel-Aziz, and Claudiu T. Supuran.  SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX. Bioorganic Chemistry 2019, 83, 549–558. https://doi.org/10.1016/J.BIOORG.2018.11.014

Wagdy M. Eldehna, Mahmoud F. Abo-Ashour, Alessio Nocentini, Radwan S. El-Haggar, Silvia Bua, Alessandro Bonardi, Sara T. Al-Rashood, Ghada S. Hassan, Paola Gratteri, Hatem A. Abdel-Aziz, and Claudiu T. Supuran.  Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents. European Journal of Medicinal Chemistry 2019, 162, 147–160. https://doi.org/10.1016/J.EJMECH.2018.10.068

Wagdy M. Eldehna, Ghada S. Hassan, Sara T. Al-Rashood, Tarfah Al-Warhi, Ahmed E. Altyar, Hamad M. Alkahtani, Abdulrahman A. Almehizia, and Hatem A. Abdel-Aziz.  Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents. Journal of Enzyme Inhibition and Medicinal Chemistry 2019, 34(1), 322–332. 10.1080/14756366.2018.1547286

Ahmed Elkamhawy, Ahmed H. E. Hassan, Sora Paik, Yong S. Lee, Hwi H. Lee, Ji S. Shin, Kyung T. Lee, and Eun J. Roh.  EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl) phenoxy) pyrimidin-5-yl) benzamide as a novel anti-inflammatory EGFR inhibitor. Bioorganic Chemistry 2019, 86, 112–118. https://doi.org/10.1016/J.BIOORG.2019.01.017

Ahmed Elkamhawy, Nam Y. Kim, Ahmed H. E. Hassan, Jung E. Park, Jeong E. Yang, Mohamed H. Elsherbeny, Sora Paik, Kwang S. Oh, Byung H. Lee, Mi Y. Lee, Kye J. Shin, Ae N. Pae, Kyung T. Lee, and Eun J. Roh.   Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation. Bioorganic Chemistry 2019, 92, 103261. https://doi.org/10.1016/J.BIOORG.2019.103261

Ahmed K. Farag, Ahmed H. E. Hassan, Hyeanjeong Jeong, Youngji Kwon, Jin G. Choi, Myung S. Oh, Ki D. Park, Yun K. Kim, and Eun J. Roh.  First-in-class DAPK1/CSF1R dual inhibitors: Discovery of 3,5-dimethoxy-N-(4-(4-methoxyphenoxy)-2-((6-morpholinopyridin-3-yl) amino) pyrimidin-5-yl) benzamide as a potential anti-tauopathies agent. European Journal of Medicinal Chemistry 2019, 162, 161–175. https://doi.org/10.1016/J.EJMECH.2018.10.057

Moustafa T. Gabr, Mostafa M. H. Ibrahim, Anuj Tripathi, and Chetti Prabhakar.  A Coumarin-Benzothiazole Derivative as a FRET-Based Chemosensor of Adenosine 5′-Triphosphate. Chemosensors 2019, 7(3), 34. https://doi.org/10.3390/chemosensors7030034

Moustafa T. Gabr, and F. Christopher Pigge.  Expanding the Toolbox for Label-Free Enzyme Assays: A Dinuclear Platinum (II) Complex/DNA Ensemble with Switchable Near-IR Emission. Molecules 2019, 24(23), 4390. https://doi.org/10.3390/MOLECULES24234390

Mahmoud M. Gamal El-Din, Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Kyung H. Yoo, and Chang H. Oh. Design, synthesis, in vitro potent antiproliferative activity, and kinase inhibitory effects of new triarylpyrazole derivatives possessing different heterocycle terminal moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 2019, 34(1), 1534–1543. https://doi.org/10.1080/14756366.2019.1653292

Halil Gökce, Yusuf Sert, Gökhan Alpaslan, Adel S. El-Azab, Mohammed M. Alanazi, Mohamed H. M. Al-Agamy, and Alaa A. M. Abdel-Aziz. Hirshfeld Surface, Molecular Docking Study, Spectroscopic Characterization and NLO Profile of 2-Methoxy-4,6-Diphenylnicotinonitrile. ChemistrySelect 2019, 4(33), 9857–9870. https://doi.org/10.1002/SLCT.201902391

Hebat Allah M. Goma’a, Mariam A. Ghaly, Laila A. Abou-zeid, Farid A. Badria, Ihsan A. Shehata, and Mohamed M. El-Kerdawy.  Synthesis, Biological Evaluation and In Silico Studies of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives as Antiherpetic Agents. ChemistrySelect 2019, 4(21), 6421–6428. https://doi.org/10.1002/SLCT.201900814

Mogedda E. Haiba, Ebtehal S. Al-Abdullah, Nesreen S. Ahmed, Hazem A. Ghabbour, and Hanem M. Awad.  Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents. Journal of Molecular Structure 2019, 1195, 702–711. https://doi.org/10.1016/J.MOLSTRUC.2019.05.081

Noha Hasaneen, Abdelaziz Ebead, Murtaza Hassan, Hanan Afifi, Howard Hunter, Edward Lee-Ruff, Nadia S. El-Gohary, Azza R. Maarouf, and Ali A. El-Emam.   Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives. Molecules 2019, 24(18). https://doi.org/10.3390/MOLECULES24183235

Ahmed H. E. Hassan, Eunwoo Choi, Yoon M. Yoon, Kun W. Lee, Sung Y. Yoo, Min C. Cho, Ji S. Yang, Hye I. Kim, Joo Y. Hong, Ji S. Shin, Kyung S. Chung, Jeong H. Lee, Kyung T. Lee, and Yong S. Lee.   Natural products hybrids: 3,5,4’-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells. European Journal of Medicinal Chemistry 2019, 161, 559–580. https://doi.org/10.1016/J.EJMECH.2018.10.062

Ahmed H. E. Hassan, Sung Y. Yoo, Kun W. Lee, Yoon M. Yoon, Hye W. Ryu, Youngdo Jeong, Ji S. Shin, Shin Y. Kang, Seo Y. Kim, Hwi H. Lee, Boyoung Y. Park, Kyung T. Lee, and Yong S. Lee.  Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators. European Journal of Medicinal Chemistry 2019, 180, 253–267. https://doi.org/10.1016/J.EJMECH.2019.07.030

Samia S. Hawas, Nadia S. El-Gohary, Moustafa T. Gabr, Mona I. Shaaban, and Mahmoud B. El-Ashmawy.  Synthesis, molecular docking, antimicrobial, antiquorum-sensing and antiproliferative activities of new series of pyrazolo[3,4-b]pyridine analogs. Synthetic Communications 2019, 49(19), 2466–2487. https://doi.org/10.1080/00397911.2019.1618873

Serdal Kaya, Halil Gökce, Adel S. El-Azab, Yusuf Sert, Mohammed M. Alanazi, Nuri Öztürk, Mohamed H. M. Al-Agamy, and Alaa A. M. Abdel-Aziz.  Structural, Spectroscopic, Electronic and Molecular Docking Studies on (11R,12 S)-16-Aminotetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9(14),10,12-hexaen-15-ol. ChemistrySelect 2019, 4(3), 825–837. https://doi.org/10.1002/SLCT.201803732

Lamya, H., Aisha Alsfouk, Ali A. El Emam, and Olivier Blacque.  Crystal structures and Hirshfeld surface analysis of 2-(adamantan-1-yl)-5-(4-fluorophenyl)-1,3,4-oxadiazole and 2-(adamantan-1-yl)-5-(4-chlorophenyl)-1,3,4-oxadiazole. Acta Crystallographica Section E: Crystallographic Communications 2019, 75(5), 611–615. https://doi.org/10.1107/S2056989019004651

126873. Lotfy, Mohamed M. Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Yasmine M. Abdel Aziz, Saied M. Soliman, Abdullah M. Al-Majid, Hazem A. Ghabbour, and A. Barakat. Syntheses and X-ray crystal structures combined with conformational and Hirshfeld analyses of chalcones based on a cyclohexanone scaffold. Journal of Molecular Structure 2019, 1198, 126873. https://doi.org/10.1016/J.MOLSTRUC.2019.126873

Gehad Lotfy, Yasmine M. Abde. Aziz, Mohamed M. Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Assem Barakat, Hazem A. Ghabbour, Sammer Yousuf, Zaheer Ul-Haq, and M. Iqbal Choudhary.  Synthesis of Oxindole Analogues, Biological Activity, and In Silico Studies. ChemistrySelect 2019, 4(35), 10510–10516. https://doi.org/10.1002/SLCT.201901228

Yahia N. Mabkhot, Jamal M. A. Khaled, Mujeeb A. S. Sultan, Naiyf S. H. A. Alharbi, Salim S. Al-Showiman, Hazem A. Ghabbour, Abdulrahman Alsayari, Abdullatif Bin Muhsinah, and H. Algarni.  The novel economical synthesis and antimicrobial activity of a trithiocarbonate derivative. Bioorganic Chemistry 2019, 91, 103157. https://doi.org/10.1016/J.BIOORG.2019.103157

Michael Schultz, Mengshi Li, Jennifer Bjorklund, Moustafa T. Gabr, Dongyoul Lee, Edwin Sagastume, Frances Johnson, F Christopher Pigge, Sara Mason, Frederic Boschetti.  Evaluation of a new dicarboxy-monoamide-tetraaza-bifunctional chelator for rapid room temperature labeling of lead and copper radionuclides for radiopharmaceuticals. Journal of Labelled Compounds & Radiopharmaceuticals 2019, S283–S284. https://beta.aminer.cn/pub/5fc6bff3e8bf8c1045f5113c/evaluation-of-a-new-dicarboxy-monoamide-tetraaza-bifunctional-chelator-for-rapid-room

Moustafa T. Gabr, F. Christopher Pigge.  Expanding the Toolbox for Label-Free Enzyme Assays: A Dinuclear Platinum(II) Complex/DNA Ensemble with Switchable Near-IR Emission. Molecules 2019, 24(23), 4390. https://doi.org/10.3390/molecules24234390

Nahed N. E. El-Sayed, Norah M. Almaneai, Saied M. Soliman, Abir Ben Bacha and Hazem A. Ghabbour.  Synthesis, Structural Investigation, Antiphospholipases, Antiproteases and Antimicrobial Activities of 2-(4-hydroxy-3-methoxy-benzylidene)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one and 4 (4 hydroxy-3-methoxy-phenyl)-8-methoxy-3,4,5,6-tetrahydro-1H-benzo[h. Journal of The Chemical Society of Pakistan 2019, 41(6), 1074–1089. https://jcsp.org.pk/issueDetail.aspx?aid=12b0ecbd-a492-4c80-8e79-564fcbcbffac

Dina M. Omran, Mariam A. Ghaly, Shahenda M. El-Messery, Farid A. Badria, Ehab Abdel-Latif, and Ihsan A. Shehata.  Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies. Bioorganic Chemistry 2019, 88, 102917. https://doi.org/10.1016/J.BIOORG.2019.04.011

Mohamed A. Sabry, Heba A. Ewida, Ghada S. Hassan, Mariam A. Ghaly, and Hussein I. El-Subbagh.  Synthesis, antitumor testing and molecular modeling study of some new 6-substituted amido, azo or thioureido-quinazolin-4(3H)-ones. Bioorganic Chemistry 2019, 88. https://doi.org/10.1016/J.BIOORG.2019.102923

Omayma R. Saleh, Moataz A. Shaldum, Reham M. Goda, Ihsan A. Shehata, and Mahmoud B. El-Ashmawy.  Synthesis and Antibacterial Evaluation of New2-Phenylbenzimidazole Derivatives. ChemistrySelect 2019, 4(35), 10307–10315. https://doi.org/10.1002/SLCT.201902227

Mohammad H. Semreen, Mohammed I. El-Gamal, Saif Ullah, Saquib Jalil, Sumera Zaib, Hanan S. Anbar, Joanna Lecka, Jean Sévigny, and Jamshed Iqbal  Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors. Bioorganic & Medicinal Chemistry 2019, 27(13), 2741–2752. https://doi.org/10.1016/J.BMC.2019.04.031

Jeong M. Seo, Ahmed H. E. Hassan, and Yong S. Lee.  An expeditious entry to rare tetrahydroimidazo[1,5-c]pyrrolo[1,2-a]pyrimidin-7(8H)-ones: A single-step gateway synthesis of glochidine congeners. Tetrahedron 2019, 75(51). https://doi.org/10.1016/J.TET.2019.130760

Yusuf Sert, Lamya H. Al-Wahaibi, Halil Gökce, Hanan M. Hassan, Aisha Alsfouk, and Ali A. El-Emam.  Molecular docking, Hirshfeld surface analysis and spectroscopic investigations of 1-(adamantan-1-yl)-3-(4-fluorophenyl) thiourea: A potential bioactive agent. Chemical Physics Letters 2019, 735, 136762. https://doi.org/10.1016/J.CPLETT.2019.136762

Isha Singh, Ali A. El-Emam, Shilendra K. Pathak, Ruchi Srivastava, Vikas K. Shukla, Onkar Prasad, and Leena Sinha.  Experimental and theoretical DFT (B3LYP, X3LYP, CAM-B3LYP and M06-2X) study on electronic structure, spectral features, hydrogen bonding and solvent effects of 4-methylthiadiazole-5-carboxylic acid. Molecular Simulation 2019, 45(13), 1029–1043. https://doi.org/10.1080/08927022.2019.1629434

Hamadeh Tarazi, Mohammed I. El-Gamal, and Chang H. Oh.  Discovery of highly potent V600E-B-RAF kinase inhibitors: Molecular modeling study. Bioorganic & Medicinal Chemistry 2019, 27(4), 655–663. https://doi.org/10.1016/J.BMC.2019.01.004

Joo Y. Hong, Chung K. Sook, Shin J. Sun, Lee J. Hun, Gil H. Sun, Lee H. Ho, Eunwoo Choi, Choi J. Hye, Ahmed H. E. Hassan, Yong S. Lee, and Lee K. Tae.  The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation. Cancers 2019, 11(12). https://doi.org/10.3390/CANCERS11121927

Seyed O. Zaraei, Abduelmula R. Abduelkarem, Hanan S. Anbar, Sara Kobeissi, Miami Mohammad, Aya Ossama, and Mohammed I. El-Gamal. Sulfamates in drug design and discovery: Pre-clinical and clinical investigations. European Journal of Medicinal Chemistry 2019, 179, 257–271. https://doi.org/10.1016/J.EJMECH.2019.06.052

Seyed O. Zaraei, Mohammed I. El-Gamal, Zainab Shafique, Sayyeda T. Amjad, Saifullah Afridi, Sumera Zaib, Hanan S. Anbar, R. El-Gamal, and Jamshed Iqbal. Sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as potent carbonic anhydrase II/IX/XII inhibitors. Bioorganic & Medicinal Chemistry 2019, 27(17), 3889–3901. https://doi.org/10.1016/J.BMC.2019.07.026