Credit Hours ( 2 + 0)

كيمياء عضوية متقدمة

Advanced Organic Chemistry

POM-201

The course is designed to discuss some new reactions and mechanisms in organic chemistry with special emphasis on reactions related to synthesis of pharmaceutical compounds. As pericyclic reactions, Radical and carbene reactions, The Role of Protective Groups in Organic Synthesis:

Credit Hours ( 2 + 0)

الكيمياء الحلقية الغير متجانسة

Heterocyclic Chemistry

POM-202

The course covers an in-depth knowledge of the chemistry of heterocyclic compounds with particular emphasis on the synthesis, reactions, and stereochemistry of different three, four, five and six member heterocycles.

Credit Hours ( 2 + 0 )

إثبات التركيب البنائي للأدوية

Structural Elucidation of Drugs

POM-203

Application of combined spectroscopic techniques e.g. UV, IR, 1H-NMR, 13C-NMR, TOCSY, MS, DEPT, APT, HMQC , HMBC, NOESY…etc in the identification of different classes of compounds.

This course covers the theory and background to chirality and provides an overview of the effects of enantiomers at biological receptors. It also includes the use of chiral compounds as drugs, and the application of chirality as a tool in Pharm. Organic Chemistry to obtain better potency, selectivity, and duration of action of drugs through the study of the topics:

Credit Hours ( 2 + 0 )

النمذجة الجزيئية وتطوير الأدوية

Molecular Modeling and Drug Development

POM-204

The course covers the concepts of molecular modeling and simulation; and provides an overview of computational chemistry techniques, ranging from the fundamental theoretical basis of modeling techniques to their application.This course covers the drug discovery process from the beginning through the final stages of clinical trials. The various stages of identifying and selecting a target, selecting and optimizing a lead compound, carrying out of in-vitro and in-vivo testing to determine biological activity and/or toxicity and evaluating acceptable "drug-like" properties are discussed.  

Credit Hours ( 2 + 0 )

الكيمياء الفراغية للأدوية

Stereochemistry of Drugs

POM-205

This course covers the theory and background to chirality and provides an overview of the effects of enantiomers at biological receptors. It also includes the use of chiral compounds as drugs, and the application of chirality as a tool in Pharm. Organic Chemistry to obtain better potency, selectivity, and duration of action of drugs through the study of the topics:

Introduction, Chirality and chiral drug development, Elements of symmetry, Stereochemistry and chemical R , Conformation, isosterism, anomeric affect importance of chirality on bioactivity of pharmacologically active drugs, Stereochemistry and drug design, Resolution, Some synthetic routes for chiral drugs  

First Semester

Credit Hours ( 2 + 0 )

Organometallic Chemistry

POP-301

Organometallic compounds, Coordination compounds with organic ligand, Structure and properties, Applications, Concepts and techniques: oxidative addition and reductive elimination, transmetalation, carbometalation, Hydrometalation, electron transfer, beta-hydride elimination, organometallic substitution reaction, carbon-hydrogen bond activation, cyclometalation, Migratory insertion, Organometallics

Credit Hours ( 2 + 0 )

Bioorganic Chemistry

POP -302

Carbohydrates

Classification of Carbohydrates, Fischer Projection for depicting Carbohydrate, Furanose and pyranose forms, Hemiacetal formation and cyclic structures of monosaccharides, Stereochemistry of monosaccharides, Mutarotation. Disaccharides and polysaccharides, Oxidation and reduction of carbohydrates, Chain extension and reduction, Other important carbohydrates, Carbohydrates on cell surface.

Amino Acids

Classification of amino acids, Structure of amino acids, Dipolar structure, Isoelectric point, Synthesis of amino acids, Resolution of R,S amino acids, Covalent bonding in peptides, Reactions of amino acids, Peptide synthesis.

Second Semester

Credit Hours ( 2 + 0 )

New Trends in Drug Synthesis

POP -303

Nanochemistry

The course covers an in-depth knowledge of the chemistry of Fundamental concepts, Current research , Bottom-up approaches, Top-down approaches, Functional approaches, Biomimetic approaches, Speculative, Tools and techniques, Applications, Implications.

Combinatorial Chemistry

The course focuses on the in-depth studies of Principle of combinatorial chemistry, Combinatorial synthesis on solid-phase, Synthesis of a combinatorial library, Determination of product structure, Range and evolution of solid-phase chemistry, Combinatorial synthesis in solution (carbamates library), Techniques for solution-phase synthesis, Solution Phase Synthesis: Scavenger Resins (ureas & sulfonamides synthesis), Solution Phase Synthesis: Fluorous technology

Green Chemistry

The course focuses on the in-depth studies of Principles, Presidential Green Chemistry Challenge Awards, Other awards, Trends, Laws, Examples, Supramolecular chemistry, Natural Product Synthesis, Reducing market barriers, Education, Laboratory chemicals, Organometallic chemicals, Scientific uncertainty

Credit Hours ( 2 + 0 )

Advanced Heterocyclic Chemistry

POP -304

The course covers an in-depth knowledge of the chemistry of heterocyclic compounds with particular emphasis on the synthesis, reactions, and stereochemistry of different three, four, five and six member heterocycles.

Credit Hours ( 2 + 0 )

Total Synthesis of Natural Products

POP -305

The course covers an in-depth knowledge of the chemistry of Natural Products with particular emphasis on Target selection, Retrosynthesis, Strategic bonds in rings, Asymmetric Synthesis, Multi-step Synthesis, Selected synthetic strategies.