High fat diet (HFD) induced Obesity

Globally, obesity is considered the fifth major cause of mortality. Obesity is the cause of 2.8 million adult's death each year. It is the result of imbalance between energy storage (food intake) and energy expenditure, which lead to excessive abnormal fat accumulation in the body.

Several studies have reported that over-feeding of animals with HFD generates a valid rodents’ model of hyperglycemia, obesity and whole-body insulin resistance. Therefore, HFD in research is used for induction of metabolic syndrome in rodents.

Signaling Pathway:

Several signaling pathways reported to be involved in obesity. However, chronic low-grade inflammation (e.g. IL-1α, IL-1β, IL-6, RANTES, MCP-1, TNFα) contributes to obesity and may be an important cause of insulin resistance, Type 2 diabetes mellitus and obesity Complications.

Induction of HFD induced Obesity

High fat diet-induced obesity: rats fed a fatty diet composed of 17% carbohydrate, 25% protein and 58% fat, as a percentage of total kcal for 10 weeks with water available ad libitum.