Lung Fibrosis

Pulmonary fibrosis is a kind of chronic interstitial lung disease, causing cough, dyspnea and even respiratory failure. Pulmonary fibrosis is characterized by abnormal wound healing associated with chronic, progressive, irreversible fatal lung disease, leading to persistent injuries to the alveolar epithelium.

Signaling Pathway:

TGF-β, Wnt, hedgehog, Notch, and fibroblast growth factor (FGF) signaling pathways play a vital role in driving aberrant wound healing response, Extracellular matrix deposition, Epithelial to mesenchymal transition and cellular senescence. Therefore, contributes to the development of pulmonary fibrosis.

Induction of Lung Fibrosis:

Intratracheal administration of single dose 0.1 mL of bleomycin (5 mg/kg in 0.9% NaCl).