Derivatization of natural products by chemical or biological transformations.
Derivatization of natural products by chemical or biological transformations.
| A new pimarane-type diterpene, namely, 8,15R-epoxy,16-hydroxy-pimaran-19-oic acid 1 was obtained from the biotransformation of 8β-hydroxypimar-15-en-19-oic acid 2 using a filamentous fungus, Cordyceps sinensis. Both compounds were in vitro tested for their cytotoxic effects against human colorectal carcinoma (HCT-116) cells. In addition, their selectivity was examined using the normal human fibroblast cells, HF-19 and TIG-1. The new metabolite 1 exhibited potent cytotoxic activity against HCT-116 (IC50 7.53 μM) with no cytotoxicity against TIG-1 and HF-19. |