الهدف الرئيسى لهذه الجائزة السنوية هو تحفيز روح التنافس والتميز على مستوى الموظفين من جهة، وعلى مستوى المؤسسات الحكومية من جهة أخرى. ويتم تكريم المتميزين في أداء الخدمات العامة تكريماً معنوياً ومادياً مما يرسخ قيم العطاء والانتماء والتميز

Pharmacology and toxicology Publications 2022

  • Zaghloul, M. S., Elshal, M., Abdelmageed, M. E. (2022). Preventive empagliflozin activity on acute acetic acid-induced ulcerative colitis in rats via modulation of SIRT-1/PI3K/AKT pathway and improving colon barrier. Environmental Toxicology and Pharmacology. https://doi.org/10.1016/j.etap.2022.103833.
  • Elshal, M., Abdelmageed, M.E (2022). Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways. Arch. Pharm. Res. https://doi.org/10.1007/s12272-022-01373-7.
  • Samaha, M.M., Helal, M.G., El-Sherbiny, M., Said, E., Salem, H.A. Diacerein versus adipoRon as adiponectin modulators in experimentally-induced end-stage type 2 diabetes mellitus in rats. Environmental Toxicology and Pharmacology, 2022, 90, 103806. https://doi.org/10.1016/j.etap.2021.103806
  • Mohamed, N.I., El-Kashef, D.H., Suddek, G.M. Flavocoxid halts both intestinal and extraintestinal alterations in acetic acid-induced colitis in rats. Environmental Science and Pollution Research, 2022, 29(4), pp. 5945–5959 https://doi.org/10.1007/s11356-021-16092-7
  • Mohamed, N.I., Suddek, G.M., El-Kashef, D.H. Corrigendum: “Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis”. International Immunopharmacology, 2022, 108575. https://doi.org/10.1016/j.intimp.2022.108575
  • Khaled, S., Makled, M.N., Nader, M.A. Protective effects of propolis extract against nicotine-evoked pulmonary and hepatic damage. Environmental Science and Pollution Research, 2022, 29(4), pp. 5812–5826. https://doi.org/10.1007/s11356-021-16093-6
  • Gomaa, H.A.M., Shaker, M.E., Alzarea, S.I., ...Trembleau, L., Youssif, B.G.M. Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities. Bioorganic Chemistry, 2022, 120, 105616. http://dx.doi.org/10.1016/j.bioorg.2022.105616
  • Shaker, M.E., Hendawy, O.M., El-Mesery, M., Hazem, S.H. The JAK inhibitor ruxolitinib abrogates immune hepatitis instigated by concanavalin A in mice. International Immunopharmacology, 2022, 103, 108463. https://doi.org/10.1016/j.intimp.2021.108463
  • Shaker, M.E., Hamed, M.F., Shaaban, A.A. Digoxin mitigates diethylnitrosamine-induced acute liver injury in mice via limiting production of inflammatory mediators. Saudi Pharmaceutical Journal, 2022. https://doi.org/10.1016/j.jsps.2022.01.007
  • Darwish, S.A., El-Kerdawy, M.M., Elsheakh, A.R., ...Hassan, G.S., Ghaly, M.A. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies. Bioorganic Chemistry, 2022, 120, 105644. https://doi.org/10.1016/j.bioorg.2022.105644
  • Waly, O.M., Saad, K.M., El-Subbagh, H.I., Bayomi, S.M., Ghaly, M.A. Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents. European Journal of Medicinal Chemistry, 2022, 231, 114152 https://doi.org/10.1016/j.ejmech.2022.114152
  • Madkour, A. H., Helal, M. G., Said, E., & Salem, H. A. Dose-dependent renoprotective impact of Lactoferrin against glycerol-induced rhabdomyolysis and acute kidney injury. Life Sciences, 2022, 120646. https://doi.org/10.1016/j.lfs.2022.120646.
  •  Samaha, M. M., Helal, M. G., El-Sherbiny, M., Said, E., & Salem, H. A. Indapamide Increases IRS1 Expression and Modifies Adiponectin/NLRP3/PPARγ Crosstalk in Type 2 Diabetic Rats. Antioxidants, 2022, 11(4), 691. https://doi.org/10.3390/antiox11040691.
  • El-Sherbiny, M., El-Shafey, M., Said, E., Shaker, G. A., El-Dosoky, M., Ebrahim, H. A., ... & Elsherbiny, N. M. Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation. Life, 2022, 12(5), 764. https://doi.org/10.3390/life12050764
  • Abdelrahman, R. S., Abdelsalam, R. A., & Zaghloul, M. S. Beneficial effect of trimetazidine on folic acid‐induced acute kidney injury in mice: Role of HIF‐1α/HO‐1. Journal of Biochemical and Molecular Toxicology, 2022, 36(5), e23011. https://doi.org/10.1002/jbt.23011.
  • Abdelrahman, R. S., & Shawky, N. M. Trimetazidine, a metabolic modulator, attenuates silica‐induced pulmonary fibrosis and decreases lactate levels and LDH activity in rats. Journal of Biochemical and Molecular Toxicology, 2022, e23071. https://doi.org/10.1002/jbt.23071.
  • Abdelrahman, R. S., & El-Tanbouly, G. S. Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/IL-17/IL-23 immunoinflammatory pathway. Toxicology and Applied Pharmacology, 2022, 440, 115931. https://doi.org/10.1016/j.taap.2022.115931.
  • El Sayed, M. T., El-Sharief, M. A., Zarie, E. S., Morsy, N. M., Elsheakh, A. R., Voronkov, A., ... & Hassan, G. S. Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as cyclooxygenase enzyme (COX) inhibitors (vol 28, pg 952, 2018). Bioorganic & medicinal chemistry letters,2022, 61.https://doi.org/10.1016/j.bmcl.2018.01.043
  • El Sayed, M. T., El-Sharief, M. A. S., Zarie, E. S., Morsy, N. M., Elsheakh, A. R., Nayel, M., ... & Abdel-Aziz, H. A. Corrigendum to" Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential Naprosyn® analogs as COX-1 and/or COX-2 inhibitors"[Bioorg. Chem. 76 (2018) 188-201]. Bioorganic chemistry, 2022, 122, 105753. https://doi.org/10.1016/j.bioorg.2022.105753.
  • Makled, M. N., Serrya, M. S., & El‐Sheakh, A. R. Fingolimod ameliorates acetic acid‐induced ulcerative colitis: An insight into its modulatory impact on pro/anti‐inflammatory cytokines and AKT/mTOR signalling. Basic & Clinical Pharmacology & Toxicology, 2022, 130(5), 569-580. https://doi.org/10.1111/bcpt.13720.
  • Al-Wakeel, D. E., El-Kashef, D. H., & Nader, M. A. Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-κB axis. Life Sciences,2022, 120633. https://doi.org/10.1016/j.lfs.2022.120633.
  • Zaghloul, R. A., Zaghloul, A. M., & El-Kashef, D. H. Hepatoprotective effect of Baicalin against thioacetamide-induced cirrhosis in rats: Targeting NOX4/NF-κB/NLRP3 inflammasome signaling pathways. Life Sciences, 2022, 295, 120410. https://doi.org/10.1016/j.lfs.2022.120410.
  • Abdelgawad, M. A., Mohamed, F. E., Lamie, P. F., Bukhari, S. N., Al-Sanea, M. M., Musa, A., ... & Kandeel, M. M. Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells. Bioorganic Chemistry, 2022, 122, 105752. https://doi.org/10.1016/j.bioorg.2022.105752.
  • Shaker, M. E. The contribution of sterile inflammation to the fatty liver disease and the potential therapies. Biomedicine & Pharmacotherapy, 2022, 148, 112789. https://doi.org/10.1016/j.biopha.2022.112789.
  • Shawky, N. M., Dalmasso, C., Ojeda, N. B., Zuchowski, Y., Stachenfeld, N., Alexander, B. T., & Reckelhoff, J. F. Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II. Journal of hypertension, 2022, 40(4), 712-722. https://doi.org/10.1097/HJH.0000000000003067.
  • El-Huneidi, W., Anjum, S., Saleh, M. A., Bustanji, Y., Abu-Gharbieh, E., & Taneera, J. Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake. Molecules, 2022, 27(7), 2102. https://doi.org/10.3390/molecules27072102.
  • Zaghloul, M. S., Elshal, M., & Abdelmageed, M. E. Preventive empagliflozin activity on acute acetic acid-induced ulcerative colitis in rats via modulation of SIRT-1/PI3K/AKT pathway and improving colon barrier. Environmental Toxicology and Pharmacology, 2022, 91, 103833. https://doi.org/10.1016/j.etap.2022.103833.

 

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شارع الجمهورية - المنصورة - محافظة الدقهلية

 2246253 050

  vice.dean-pharmacy@mans.edu.eg

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