الهدف الرئيسى لجائزة مصر للتميز الحكومى السنوية هو تحفيز روح التنافس والتميز على مستوى الموظفين من جهة، وعلى مستوى المؤسسات الحكومية من جهة أخرى. ويتم تكريم المتميزين في أداء الخدمات العامة تكريماً معنوياً ومادياً مما يرسخ قيم العطاء والانتماء والتميز، ويحفز الجميع على الارتقاء بمستويات الأداء والالتزام بمعايير الجودة والتميز.

جائزة مصر للتميز الحكومى

Pharmacology and toxicology Publications 2021

 

  • Makled, M.N., El-Awady, M.S., Abdel-Aziz, R.R., .Ammar, E.M., Gameil, N.M. Pomegranate extract ameliorates renal ischemia/reperfusion injury in rats via suppressing NF-κB pathway. Human and Experimental Toxicology, 2021, 40(12_suppl), pp. S573–S582. https://doi.org/10.1177/09603271211041998
  • Elsayed, M.S., Abu-Elsaad, N.M., Nader, M.A. The NLRP3 inhibitor dapansutrile attenuates folic acid induced nephrotoxicity via inhibiting inflammasome/caspase-1/IL axis and regulating autophagy/proliferation. Life Sciences, 2021, 285, 119974. https://doi.org/10.1016/j.lfs.2021.119974
  • Ibrahim, S.R.M., Altyar, A.E., Sindi, I.A., ...Mohamed, S.G.A., Mohamed, G.A. Kirenol: A promising bioactive metabolite from siegesbeckia species: A detailed review. Journal of Ethnopharmacology, 2021, 281, 114552. https://doi.org/10.1016/j.jep.2021.114552
  • Mohamed, G.A., Ibrahim, S.R.M., El-Agamy, D.S., ...Koshak, A.E., Elhady, S.S. Terretonin as a new protective agent against sepsis-induced acute lung injury: Impact on SIRT1/Nrf2/NF-κBp65/NLRP3 signaling. Biology, 2021, 10(11), 1219. https://doi.org/10.3390/biology10111219
  • Shaker, M.E., Eisa, N.H., Elgaml, A., ...El-Mowafy, M., El-Mesery, M. Ingestion of mannose ameliorates thioacetamide-induced intrahepatic oxidative stress, inflammation and fibrosis in rats. Life Sciences, 2021, 286, 120040. https://doi.org/10.1016/j.lfs.2021.120040
  • El-Sherbiny, M., Fahmy, E.K., Eisa, N.H., ...Elsherbiny, N.M., Ghoneim, F.M. Nanogold particles suppresses 5-flurouracil-induced renal injury: An insight into the modulation of nrf-2 and its downstream targets, ho-1 and γ-gcs. Molecules, 2021, 26(24),768.https://www.mdpi.com/1420-3049/26/24/7684
  • El-Sherbiny, M., Eisa, N.H., Abo El-Magd, N.F., ...Said, E., Khodir, A.E. Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into TLR4/NF-kB/caspase signalling modulation. Environmental Toxicology and Pharmacology, 2021, 88, 103750. https://doi.org/10.1016/j.etap.2021.103750
  • Sharawy, M.H., El-Kashef, D.H., Shaaban, A.A., El-Agamy, D.S. Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition. International Immunopharmacology, 2021, 100, 108088. https://doi.org/10.1016/j.intimp.2021.108088
  • Abd Elhameed, A.G., Helal, M.G., Said, E., Salem, H.A. Saxagliptin defers thioacetamide-induced hepatocarcinogenesis in rats: A novel suppressive impact on Wnt/Hedgehog/Notch1 signaling. Environmental Toxicology and Pharmacology , 2021, 86, 103668. https://doi.org/10.1016/j.etap.2021.103668
  • Abdelmageed, M.E. Shehatou, G.S.G., Suddek, G.M., Salem, H.A. Protocatechuic acid improves hepatic insulin resistance and restores vascular oxidative status in type-2 diabetic rats. Environmental Toxicology and Pharmacology , 2021, 83, 103577. https://doi.org/10.1016/j.etap.2020.103577
  • Amer, A.E., Shehatou, G.S.G., El-Kashef, H.A., Nader, M.A., El-Sheakh, A.R. Flavocoxid Ameliorates Aortic Calcification Induced by Hypervitaminosis D3 and Nicotine in Rats Via Targeting TNF-α, IL-1β, iNOS, and Osteogenic Runx2. Cardiovascular Drugs and Therapy, 2021. https://doi.org/10.1007/s10557-021-07227-6
  • Amer, A.E., El-Sheakh, A.R., Hamed, M.F., Nader, M.A., Shehatou, G.S.G. Febuxostat attenuates vascular calcification induced by vitamin D3 plus nicotine in rats. European Journal of Pharmaceutical Sciences, 2021, 156, 105580. https://doi.org/10.1016/j.ejps.2020.105580
  • Elshal, M., Abu-Elsaad, N., El-Karef, A., Ibrahim, T.M. Etanercept attenuates immune-mediated hepatitis induced by concanavalin A via differential regulation of the key effector cytokines of CD4+ T cells. Life Sciences, 2021, 277, 119618. https://doi.org/10.1016/j.lfs.2021.119618
  • Mohamed, N.I., Suddek, G.M., El-Kashef, D.H. Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis. International Immunopharmacology, 2021, 99, 108005. https://doi.org/10.1016/j.intimp.2021.108005
  • Abdelhamid, A.M., Elsheakh, A.R., Suddek, G.M. Abdelaziz, R.R. Telmisartan alleviates alcohol-induced liver injury by activation of PPAR-γ/ Nrf-2 crosstalk in mice. International Immunopharmacology, 2021, 99, 107963. https://doi.org/10.1016/j.intimp.2021.107963
  • Nour, O.A., Ghoniem, H.A., Nader, M.A., Suddek, G.M. Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats. European Journal of Pharmacology, 2021, 907, 174257. https://doi.org/10.1016/j.ejphar.2021.174257
  • Habib, S.A., Suddek, G.M., Abdel Rahim, M., Abdelrahman, R.S. The protective effect of protocatechuic acid on hepatotoxicity induced by cisplatin in mice. Life Sciences, 2021, 277, 119485. https://doi.org/10.1016/j.lfs.2021.119485
  • Mohamed, N.I., El-Kashef, D.H., Suddek, G.M. Flavocoxid halts both intestinal and extraintestinal alterations in acetic acid-induced colitis in rats. Environmental Science and Pollution Research, 2021. 29(4):5945-5959. https://doi.org/10.1007/s11356-021-16092-7
  • Sherif, D.A., Makled, M.N., Suddek, G.M. The HIV reverse transcriptase Tenofovir suppressed DMH/HFD-induced colorectal cancer in Wistar rats. Fundamental and Clinical Pharmacology, 2021. 35(6):940-954. https://doi.org/10.1111/fcp.12679
  • Abdelmageed, M.E., Nader, M.A., Zaghloul, M.S. Targeting HMGB1/TLR4/NF-κB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats. European Journal of Pharmacology, 2021, 906, 174279. https://doi.org/10.1016/j.ejphar.2021.174279
  • Serrya, M.S., Nader, M.A., Abdelmageed, M.E. Hepatoprotective effect of the tyrosine kinase inhibitor nilotinib against cyclosporine-A induced liver injury in rats through blocking the Bax/Cytochrome C/caspase-3 apoptotic signaling pathway. Journal of Biochemical and Molecular Toxicology, 2021, 35(6), pp. 1–13. https://doi.org/10.1002/JBT.22764
  • Mohamed, S.A., El-Kashef, D.H., Nader, M.A. Tiron alleviates MPTP-induced Parkinsonism in mice via activation of Keap-1/Nrf2 pathway. Journal of Biochemical and Molecular Toxicology, 2021, 35(3), e22685. https://doi.org/10.1002/jbt.22685
  • Amer, A.E., El-Sheakh, A.R., Hamed, M.F., Nader, M.A., Shehatou, G.S.G. Febuxostat attenuates vascular calcification induced by vitamin D3 plus nicotine in rats. European Journal of Pharmaceutical Sciences, 2021, 156, 105580. https://doi.org/10.1016/j.ejps.2020.105580
  • MH Sharawy, MS El‐Awady, MN Makled. Protective effects of paclitaxel on thioacetamide‐induced liver fibrosis in a rat model. Journal of Biochemical and Molecular Toxicology, 2021, e22745. https://doi.org/10.1002/jbt.22745
  • NME Hassan, GSG Shehatou, HI Kenawy, E Said‏. Dasatinib mitigates renal fibrosis in a rat model of UUO via inhibition of Src/STAT-3/NF-κB signaling‏. Environmental Toxicology and Pharmacology, 2021, 84, 103625. https://doi.org/10.1016/j.etap.2021.103625
  • NME Hassan, E Said, GSG Shehatou. Nifuroxazide suppresses UUO-induced renal fibrosis in rats via inhibiting STAT-3/NF-κB signaling, oxidative stress and inflammation‏. Life Sciences, 2021, 272, 119241‏. https://doi.org/10.1016/j.lfs.2021.119241
  • HMH Ali A El-Emam, George Shehatou, Lamya H Al-Wahaibi. Adamantane-linked isothiourea derivatives suppress the growth of experimental hepatocellular carcinoma via inhibition of TLR4-MyD88-NF-κB signaling‏. American Journal of Cancer Research, 2021, 11 (2), 350-369‏. https://www.ncbi.nlm.nih.gov/pubmed/33575076
  • Al-Sanea, M.M., Obaidullah, A.J., Shaker, M.E., ...Alsubaie, S.A., Abdelgawad, M.A. A new CDK2 inhibitor with 3-hydrazonoindolin-2-one scaffold endowed with anti-breast cancer activity: Design, synthesis, biological evaluation, and in silico insights. Molecules, 2021, 26(2), 412. https://doi.org/10.3390/molecules26020412
  • EA Nazmy, MG Helal, E Said. Nifuroxazide mitigates cholestatic liver injury by synergistic inhibition of Il-6/Β-catenin signaling and enhancement of BSEP and MDRP2 expression. International Immunopharmacology, 2021, 99, 107931. https://doi.org/10.1016/j.intimp.2021.107931
  • M Helal, M Shawky, S Elhusseiny, A Abd Elhameed. Lactoferrin Ameliorates Azithromycin-induced Cardiac Injury: Insight into Oxidative Stress/TLR4/NF-κB Pathway. Journal of Advanced Pharmacy Research, 2021, 5 (2), 285-296. https://dx.doi.org/10.21608/aprh.2021.62735.1122
  • MG Helal, AG Abd Elhameed. Graviola mitigates acetic acid–induced ulcerative colitis in rats: insight on apoptosis and Wnt/Hh signaling crosstalk. Environmental Science and Pollution Research, 2021, 1-14. https://doi.org/10.1007/s11356-021-12716-0
  • MS Serrya, AR El-Sheakh, MN Makled. Evaluation of the therapeutic effects of mycophenolate mofetil targeting Nrf-2 and NLRP3 inflammasome in acetic acid induced ulcerative colitis in rats. Life Sciences, 2021, 271, 119154. https://doi.org/10.1016/j.lfs.2021.119154
  • Eisa, N.H., Khodir, A.E., El-Sherbiny, M., Elsherbiny, N.M., Said, E. Phenethyl isothiocyanate attenuates diabetic nephropathy via modulation of glycative/oxidative/inflammatory signaling in diabetic rats. Biomedicine and Pharmacotherapy, 2021, 142, 111666.
  •  https://doi.org/10.1016/j.biopha.2021.111666
  • Makled, M.N., Said, E. Tranilast abrogates cisplatin-induced testicular and epididymal injuries: An insight into its modulatory impact on apoptosis/proliferation. Journal of Biochemical and Molecular Toxicology, 2021, 35(8), e22817. https://doi.org/10.1002/jbt.22817
  • Alzahrani, S., Said, E., Ajwah, S.M., Qushawy, M., Elsherbiny, N.M. Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury. The Journal of pharmacy and pharmacology, 2021, 73(2), pp. 193–205. https://doi.org/10.1093/jpp/rgaa056
  • Ezzat, D.M., Soliman, A.M., El-Kashef, D.H. Nicorandil mitigates folic acid-induced nephrotoxicity in mice: Role of iNOS and eNOS. Journal of Biochemical and Molecular Toxicology, 2021, 35(4), e22692. https://doi.org/10.1002/jbt.22692
  • Zuchowski, Y., Dalmasso, C., Shawky, N.M., Reckelhoff, J.F. Cardiometabolic consequences of maternal hyperandrogenemia in male offspring. Physiological Reports, 2021, 9(14), e14941. https://dx.doi.org/10.14814%2Fphy2.14941
  • Pichavaram, P., Shawky, N.M., Hartney, T.J., Jun, J.Y., Segar, L. Imatinib improves insulin resistance and inhibits injury-induced neointimal hyperplasia in high fat diet-fed mice. European Journal of Pharmacology, 2021, 890, 173666. https://doi.org/10.1016/j.ejphar.2020.173666
  • Elnfarawy, A.A., Nashy, A.E., Abozaid, A.M., ...Elweshahy, R.H., Abdelrahman, R.S. Vinpocetine attenuates thioacetamide-induced liver fibrosis in rats. Human and Experimental Toxicology, 2021, 40(2), pp. 355–368. https://doi.org/10.1177/0960327120947453
  • Abd Elhameed, A.G. Krill oil and low-dose aspirin combination mitigates experimentally induced silicosis in rats: role of NF-κB/TGF-β1/MMP-9 pathway. Environmental Science and Pollution Research, 2021, 28(15), pp. 19272–19284. https://doi.org/10.1007/s11356-020-11921-7
  • Mazyed, E.A., Helal, D.A., Elkhoudary, M.M., Abd Elhameed, A.G., Yasser, M. Formulation and optimization of nanospanlastics for improving the bioavailability of green tea epigallocatechin gallate. Pharmaceuticals, 2021, 14(1), pp. 1–30, 68. https://doi.org/10.3390/ph14010068
  • Fahmy, E.K., El-Sherbiny, M., Said, E., ...Qushawy, M., Elsherbiny, N. Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2. NeuroToxicology, 2021, 82, pp. 167–176. https://doi.org/10.1016/j.neuro.2020.12.008
  • Samra, Y.A., Amin, M.N., Said, E. Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling. International Immunopharmacology, 2021, 90, 107125. https://doi.org/10.1016/j.intimp.2020.107125
  • Elshaer, S.E., Park, H., Pearson, L., Hill, W.D., Longo, F., and El-Remessy. A.B. Modulation of p75NTR on mesenchymal stem cells increases their vascular protection in retinal ischemia-reperfusion mouse model. Int. J. Mol. Sci., 2021, 22, 829. https://www.mdpi.com/1422-0067/22/2/829
  • Elshaer, S.L., Bahram, S.H., Rajashekar, P., Gangaraju, R., El-Remessy, A.B. Modulation of Mesenchymal Stem Cells for Enhanced Therapeutic Utility in Ischemic Vascular Diseases. Int. J. Mol. Sci., 2021 23(1):249. doi: 10.3390/ijms23010249 (Review article)

 

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شارع الجمهورية - المنصورة - محافظة الدقهلية

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  vice.dean-pharmacy@mans.edu.eg

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