Publications of the Department of Pharmaceutical Organic Chemistry 2020
El-Husseiny, W.M., El-Sayed, M.A.A., El-Azab, A.S., AlSaif, N.A., Alanazi, M.M. and Abdel-Aziz, A.A.M., 2020. Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), pp.744-758. https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1740695
Farahat, A.A., Guo, P., Shoeib, H., Paul, A., Boykin, D.W. and Wilson, W.D., 2020. Small Sequence‐Sensitive Compounds for Specific Recognition of the G⋅ C Base Pair in DNA Minor Groove. Chemistry–A European Journal, 26(20), pp.4539-4551. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201904396
El Sayed, M.T., Sarhan, A.E., Ahmed, E., Khattab, R.R., Elnaggar, M., El‐Messery, S.M., Shaldam, M.A. and Hassan, G.S., 2020. Novel Pyruvate Kinase (PK) Inhibitors: New Target to Overcome Bacterial Resistance. ChemistrySelect, 5(11), pp.3445-3453. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202000043
Ewes, W.A., Elmorsy, M.A., El-Messery, S.M. and Nasr, M.N., 2020. Synthesis, biological evaluation and molecular modeling study of [1, 2, 4]-Triazolo [4, 3-c] quinazolines: New class of EGFR-TK inhibitors. Bioorganic & medicinal chemistry, 28(7), p.115373. https://www.sciencedirect.com/science/article/pii/S0968089620301693?via%3Dihub
Nashaat, S., Henen, M.A., El-Messery, S.M. and Eisa, H., 2020. Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer. Bioorganic & Medicinal Chemistry, 28(11), p.115495.https://www.sciencedirect.com/science/article/pii/S0968089620303163?via%3Dihub
Tawfik, S.S., Liu, M. and Farahat, A.A., 2020. Antiviral activity of thiadiazoles, oxadiazoles, triazoles and thiazoles. Arkivoc, pp.180-218. https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p011.308
Ashour, H.F., Abou-Zeid, L.A., Magda, A.A. and Selim, K.B., 2020. 1, 2, 3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226. European Journal of Medicinal Chemistry, 189, p.112062. https://www.sciencedirect.com/science/article/pii/S0223523420300295?via%3Dihub
El-Shafey, H.W., Gomaa, R.M., El-Messery, S.M. and Goda, F.E., 2020. Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting. Bioorganic & Medicinal Chemistry Letters, 30(15), p.127281. https://www.sciencedirect.com/science/article/pii/S0960894X20303917?via%3Dihub
El-Shafey, H.W., Gomaa, R.M., El-Messery, S.M. and Goda, F.E., 2020. Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent. Bioorganic Chemistry, 101, p.103987. https://www.sciencedirect.com/science/article/pii/S0045206820312840?via%3Dihub
Thabit, M.G., Mostafa, A.S., Selim, K.B., Elsayed, M.A. and Nasr, M.N., 2020. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorganic Chemistry, 103, p.104148. https://doi.org/10.1016/j.bioorg.2020.104148.
Elkamhawy, A., Paik, S., Kim, H.J., Park, J.H., Londhe, A.M., Lee, K., Pae, A.N., Park, K.D. and Roh, E.J., 2020. Discovery of N-(1-(3-fluorobenzoyl)-1 H-indol-5-yl) pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B. Journal of Enzyme Inhibition and
Medicinal Chemistry, 35(1), pp.1568-1580.https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1800666Al-Sanea, M.M., Elkamhawy, A., Paik, S., Lee, K., El Kerdawy, A.M., Abbas, B.S.N., Roh, E.J., Eldehna, W.M., Elshemy, H.A., Bakr, R.B. and Farahat, I.A., 2020. Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights. Bioorganic & Medicinal Chemistry, 28(13), p.115525. https://doi.org/10.1016/j.bmc.2020.115525
El-Husseiny, W.M., El-Sayed, M.A.A., El-Azab, A.S., AlSaif, N.A., Alanazi, M.M. and Abdel-Aziz, A.A.M., 2020. Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), pp.744-758. https://doi.org/10.1080/14756366.2020.1740695
Elfeky, S.M., Sobahi, T.R., Gineinah, M.M. and Ahmed, N.S., 2020. Synthesis, biological screening, and molecular docking of quinazolinone and quinazolinethione as phosphodiesterase 7 inhibitors. Archiv der Pharmazie, 353(1), p.1900211. https://onlinelibrary.wiley.com/doi/10.1002/ardp.201900211
El-Shafey, H.W., Gomaa, R.M., El-Messery, S.M. and Goda, F.E., 2020. Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent. Bioorganic Chemistry, 101, p.103987. https://doi.org/10.1016/j.bioorg.2020.103987
Ewes, W.A., Elmorsy, M.A., El-Messery, S.M. and Nasr, M.N., 2020. Synthesis, biological evaluation and molecular modeling study of [1, 2, 4]-Triazolo [4, 3-c] quinazolines: New class of EGFR-TK inhibitors. Bioorganic & medicinal chemistry, 28(7), p.115373. https://doi.org/10.1016/j.bmc.2020.115373
El-Shafey, H.W., Gomaa, R.M., El-Messery, S.M. and Goda, F.E., 2020. Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting. Bioorganic & Medicinal Chemistry Letters, 30(15), p.127281. https://doi.org/10.1016/j.bmcl.2020.127281
Nashaat S, Henen MA, El-Messery SM, Eisa H. Synthesis, State-of-The-Art NMR-Binding and Molecular Modeling Study of New Benzimidazole Core Derivatives as Pin1 Inhibitors: Targeting Breast Cancer. Bioorganic & Medicinal Chemistry. 2020:115495. https://doi.org/10.1016/j.bmc.2020.115495
Farahat, A.A., Guo, P., Shoeib, H., Paul, A., Boykin, D.W. and Wilson, W.D., 2020. Small Sequence‐Sensitive Compounds for Specific Recognition of the G⋅ C Base Pair in DNA Minor Groove. Chemistry–A European Journal, 26(20), pp.4539-4551. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201904396