Pharmacology and toxicology Publications 2020

 

  • Kseibati, M.O., Sharawy, M.H., Salem, H.A. Chrysin mitigates bleomycin-induced pulmonary fibrosis in rats through regulating inflammation, oxidative stress, and hypoxia. International Immunopharmacology, 2020, 89, 107011. https://doi.org/10.1016/j.intimp.2020.107011
  • Samaha, M.M., Said, E., Salem, H.A. Modulatory role of imatinib mesylate on pancreatic β-cells' secretory functions in an STZ rat model of diabetes mellitus. Chemico-Biological Interactions, 2020, 328, 109197. https://doi.org/10.1016/j.cbi.2020.109197
  • Awad, A.M., Saleh, M.A., Abu-Elsaad, N.M., Ibrahim, T.M. Erlotinib can halt adenine induced nephrotoxicity in mice through modulating ERK1/2, STAT3, p53 and apoptotic pathways. Scientific Reports, 2020, 10(1), 11524. https://doi.org/10.1038/s41598-020-68480-7
  • Saleh, M.A., Awad, A.M., Ibrahim, T.M., Abu-Elsaad, N.M. Small-dose sunitinib modulates p53, bcl-2, stat3, and erk1/2 pathways and protects against adenine-induced nephrotoxicity. Pharmaceuticals, 2020, 13(11), pp. 1–15, 0397. https://doi.org/10.3390/ph13110397
  • Maresh, M.M., Abdelaziz, R.R., Ibrahim, T.M. Febuxostat mitigates concanavalin A-induced acute liver injury via modulation of MCP-1, IL-1β, TNF-α, neutrophil infiltration, and apoptosis in mice. Life Sciences, 2020, 260, 118307. https://doi.org/10.1016/j.lfs.2020.118307
  • Habib, S.A., Abdelrahman, R.S., Abdel Rahim, M., Suddek, G.M. Anti-apoptotic effect of vinpocetine on cisplatin-induced hepatotoxicity in mice: The role of Annexin-V, Caspase-3, and Bax. Journal of Biochemical and Molecular Toxicology, 2020, 34(10), e22555. https://doi.org/10.1002/jbt.22555
  • Abdelhamid, A.M., Elsheakh, A.R., Abdelaziz, R.R., Suddek, G.M. Empagliflozin ameliorates ethanol-induced liver injury by modulating NF-κB/Nrf-2/PPAR-γ interplay in mice. Life Sciences, 2020, 256, 117908. https://doi.org/10.1016/j.lfs.2020.117908
  • Amin, F.M., Abdelaziz, R.R., Hamed, M.F., Nader, M.A., Shehatou, G.S.G. Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway. Life Sciences, 2020, 256, 117887. https://doi.org/10.1016/j.lfs.2020.117887
  • Abdallah, H.M., El-Agamy, D.S., Ibrahim, S.R.M., ...Safo, M.K., Malebari, A.M. Euphorbia cuneata represses LPS-induced acute lung injury in mice via its antioxidative and anti-inflammatory activities. Plants, 2020, 9(11), pp. 1–14, 1620. https://doi.org/10.3390/plants9111620
  • Ahmed, I., Elkablawy, M.A., El-Agamy, D.S., Bazarbay, A.A., Ahmed, N. Carvedilol safeguards against aspirin-induced gastric damage in rats. Human and Experimental Toxicology, 2020, 39(9), pp. 1257–1267. https://doi.org/10.1177/0960327120918306
  • Ahmed, N., El-Agamy, D.S., Mohammed, G.A., ...Elkablawy, M., Ibrahim, S.R.M. Suppression of LPS-Induced Hepato- and Cardiotoxic Effects by Pulicaria petiolaris via NF-κB Dependent Mechanism. Cardiovascular Toxicology, 2020, 20(2), pp. 121–129. https://doi.org/10.1007/s12012-019-09539-4
  • El-Agamy, D.S., Mohamed, G.A., Ahmed, N., .Mohamed, S.G.A., Ibrahim, S.R.M. Protective anti-inflammatory activity of tovophyllin A against acute lung injury and its potential cytotoxicity to epithelial lung and breast carcinomas. Inflammopharmacology, 2020, 28(1), pp. 153–163. https://doi.org/10.1007/s10787-019-00609-1
  • N Aljuhani, RS Ismail, MS El-Awady, MH Hassan. Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis. Acta Pharmaceutica, 2020, 70 (4), 515-525. https://doi.org/10.2478/acph-2020-0033
  • RS Ismail, MS El-Awady, MH Hassan. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology, 2020, 1-11. https://doi.org/10.1007/s00210-020-01823-3
  • MA Saleh, SA Antar, RM Hazem, MF El-Azab. Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways. Pharmaceuticals, 2020, 13 (11), 348. https://doi.org/10.3390/ph13110348
  • JK Prinsen, PJ Kannankeril, TN Sidorova, LV Yermalitskaya, O Boutaud. Highly reactive isolevuglandins promote atrial fibrillation caused by hypertension. Basic to Translational Science, 2020, 5 (6), 602-615. https://doi.org/10.1016/j.jacbts.2020.04.004
  • M Saber-Ayad, MA Saleh, E Abu-Gharbieh. The rationale for potential pharmacotherapy of COVID-19. Pharmaceuticals, 2020, 13 (5), 96. https://doi.org/10.3390/ph13050096
  • ME Shaker, HAM Gomaa, KS Alharbi, MM Al-Sanea, ME El-Mesery. Inhibition of Bruton tyrosine kinase by acalabrutinib dampens lipopolysaccharide/galactosamine-induced hepatic damage‏. Biomedicine & Pharmacotherapy, 2020, 131, 110736‏. https://doi.org/10.1016/j.biopha.2020.110736
  • M El-Mesery, MA Anany, SH Hazem, ME Shaker. The NEDD8-activating enzyme inhibition with MLN4924 sensitizes human cancer cells of different origins to apoptosis and necroptosis‏. Archives of Biochemistry and Biophysics, 2020, 691, 108513‏. https://doi.org/10.1016/j.abb.2020.108513
  • ME Shaker, AA Shaaban, MM El-Shafey, ME El-Mesery . The selective c-Met inhibitor capmatinib offsets cisplatin-nephrotoxicity and doxorubicin-cardiotoxicity and improves their anticancer efficacies‏. Toxicology and applied pharmacology, 2020, 398, 115018‏. https://doi.org/10.1016/j.taap.2020.115018
  • KM Saad, ME Shaker, AA Shaaban, RS Abdelrahman, E Said. The c-Met inhibitor capmatinib alleviates acetaminophen-induced hepatotoxicity‏. International immunopharmacology, 2020, 81, 106292.‏ https://doi.org/10.1016/j.intimp.2020.106292
  • AMA 2. Al-Sanea MM, Parambi DGT, Shaker ME, Elsherif HAM, Elshemy HAH, Bakr. Design, Synthesis, and In Vitro Cytotoxic Activity of Certain2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl]acetamide Derivatives.‏ Russian Journal of Organic Chemistry, 2020, 56 (3), 514-520. http://dx.doi.org/10.1134/S1070428020030239
  • MG Helal, YA Samra. Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice. Journal of biochemical and molecular toxicology, 2020, 34 (12), e22447. https://doi.org/10.1002/jbt.22447
  • MG Helal, E Said. Tranilast attenuates methotrexate‐induced renal and hepatic toxicities: Role of apoptosis‐induced tissue proliferation. Journal of biochemical and molecular toxicology, 2020, 34 (5), e22466. https://doi.org/10.1002/jbt.22466
  • YA Samra, MF Hamed, AR El‐Sheakh. Hepatoprotective effect of allicin against acetaminophen‐induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration. Journal of Biochemical and Molecular Toxicology, 2020, e22470. https://doi.org/10.1002/jbt.22470
  • EE El Naggar, EA Mohamed, TM Borg, AR El-Sheakh, MF Hamed. Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits. Drug Design, Development and Therapy, 2020, 14, 677. https://doi.org/10.2147/DDDT.S218357
  • Alzahrani, S., Ajwah, S.M., Alsharif, S.Y., ...Al-Shabrawey, M., Elsherbiny, N.M. Isoliquiritigenin downregulates miR-195 and attenuates oxidative stress and inflammation in STZ-induced retinal injury. Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 393(12), pp. 2375–2385. https://doi.org/10.1007/s00210-020-01948-5
  • Sharawy, M.H., Serrya, M.S. Pirfenidone attenuates gentamicin-induced acute kidney injury by inhibiting inflammasome-dependent NLRP3 pathway in rats. Life Sciences, 2020, 260, 118454. https://doi.org/10.1016/j.lfs.2020.118454
  • Qandeel, N.A., El-Damasy, A.K., Sharawy, M.H., Bayomi, S.M., El-Gohary, N.S. Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives. Bioorganic Chemistry, 2020, 102, 103890. https://doi.org/10.1016/j.bioorg.2020.103890
  • Makled, M.N., El-Kashef, D.H. Saroglitazar attenuates renal fibrosis induced by unilateral ureteral obstruction via inhibiting TGF-β/Smad signaling pathway. Life Sciences, 2020, 253, 117729. https://doi.org/10.1016/j.lfs.2020.117729
  • El-Kashef, D.H., Abdelrahman, R.S. Montelukast ameliorates Concanavalin A-induced autoimmune hepatitis in mice via inhibiting TNF-α/JNK signaling pathway. Toxicology and Applied Pharmacology, 2020, 393, 114931. https://doi.org/10.1016/j.taap.2020.114931
  • Amen, Y., Sherif, A.E., Shawky, N.M., ...Wink, M., Sobeh, M. Grape-leaf extract attenuates alcohol-induced liver injury via interference with Nf-κB signaling pathway. Biomolecules, 2020, 10(4), 558.  https://doi.org/10.3390/biom10040558
  • Shawky, N.M., Patil, C.N., Dalmasso, C., Drummond, H., Reckelhoff, J.F. Pregnancy Protects Hyperandrogenemic Female Rats from Postmenopausal Hypertension. Hypertension, 2020, pp. 943–952. https://doi.org/10.1161/hypertensionaha.120.15504
  • Ali, D.E., Abdelrahman, R.S., El Gedaily, R.A., ...Meselhy, M.R., Abdelsattar, E. Evaluation of the anti-inflammatory and antioxidant activities of selected resin exudates. Tropical Journal of Natural Product Research, 2020, 4(7), pp. 255–261. https://doi.org/10.26538/tjnpr/v4i7.1
  • Abdelrahman, R.S., Abdelmageed, M.E. Renoprotective effect of celecoxib against gentamicin-induced nephrotoxicity through suppressing NFκB and caspase-3 signaling pathways in rats. Chemico-Biological Interactions, 2020, 315, 1088632020. https://doi.org/10.1016/j.cbi.2019.108863
  • Helal MG, El-Kashef DH. Krill oil alleviates oxidative stress, iron accumulation and fibrosis in the liver and spleen of iron-overload rats. EnvironSci Pollut Res Int. 2020; 27(4):3950-3961. https://doi.org/10.1007/s11356-019-06983-1
  • Saad KM, Abdelrahman RS, Said E. Mechanistic perspective of protective effects of nilotinib against cisplatin-induced testicular injury in rats: Role of JNK/caspase-3 signaling inhibition. Environ Toxicol Pharmacol. 2020; 76:103334. https://doi.org/10.1016/j.etap.2020.103334
  • Kseibati MO, Shehatou GSG, Sharawy MH, Eladl AE, Salem HA. Nicorandil ameliorates bleomycin-induced pulmonary fibrosis in rats through modulating eNOS, iNOS, TXNIP and HIF-1α levels. Life Sci. 2020; 246:117423. https://doi.org/10.1016/j.lfs.2020.117423
  • Elsherbiny NM, Said E, Atef H, Zaitone SA. Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression. Chem Biol Interact. 2020; 315:108897. https://doi.org/10.1016/j.cbi.2019.108897
  • El-Far YM, Elsherbiny NM, El-Shafey M, Said E. The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats. Environ Toxicol Pharmacol. 2020; 79:103433. https://doi.org/10.1016/j.etap.2020.103433
  • Ashry NA, Abdеlaziz RR, Suddеk GM. The potential effect of imatinib against hypercholesterolemia induced atherosclerosis, endothelial dysfunction and hepatic injury in rabbits. Life Sci. 2020; 243:117275. https://doi.org/10.1016/j.lfs.2020.117275
  • Serrya MS, Zaghloul MS. Mycophenolate mofetil attenuates concanavalin A-induced acute liver injury through modulation of TLR4/NF-κB and Nrf2/HO-1 pathways. Pharmacol Rep. 2020; 72(4):945-955. https://doi.org/10.1007/s43440-019-00055-4

 

 

 

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