الهدف الرئيسى لجائزة مصر للتميز الحكومى السنوية هو تحفيز روح التنافس والتميز على مستوى الموظفين من جهة، وعلى مستوى المؤسسات الحكومية من جهة أخرى. ويتم تكريم المتميزين في أداء الخدمات العامة تكريماً معنوياً ومادياً مما يرسخ قيم العطاء والانتماء والتميز، ويحفز الجميع على الارتقاء بمستويات الأداء والالتزام بمعايير الجودة والتميز.

جائزة مصر للتميز الحكومى

Pharmacology and toxicology Publications 2020

 

  • Kseibati, M.O., Sharawy, M.H., Salem, H.A. Chrysin mitigates bleomycin-induced pulmonary fibrosis in rats through regulating inflammation, oxidative stress, and hypoxia. International Immunopharmacology, 2020, 89, 107011. https://doi.org/10.1016/j.intimp.2020.107011
  • Samaha, M.M., Said, E., Salem, H.A. Modulatory role of imatinib mesylate on pancreatic β-cells' secretory functions in an STZ rat model of diabetes mellitus. Chemico-Biological Interactions, 2020, 328, 109197. https://doi.org/10.1016/j.cbi.2020.109197
  • Awad, A.M., Saleh, M.A., Abu-Elsaad, N.M., Ibrahim, T.M. Erlotinib can halt adenine induced nephrotoxicity in mice through modulating ERK1/2, STAT3, p53 and apoptotic pathways. Scientific Reports, 2020, 10(1), 11524. https://doi.org/10.1038/s41598-020-68480-7
  • Saleh, M.A., Awad, A.M., Ibrahim, T.M., Abu-Elsaad, N.M. Small-dose sunitinib modulates p53, bcl-2, stat3, and erk1/2 pathways and protects against adenine-induced nephrotoxicity. Pharmaceuticals, 2020, 13(11), pp. 1–15, 0397. https://doi.org/10.3390/ph13110397
  • Maresh, M.M., Abdelaziz, R.R., Ibrahim, T.M. Febuxostat mitigates concanavalin A-induced acute liver injury via modulation of MCP-1, IL-1β, TNF-α, neutrophil infiltration, and apoptosis in mice. Life Sciences, 2020, 260, 118307. https://doi.org/10.1016/j.lfs.2020.118307
  • Habib, S.A., Abdelrahman, R.S., Abdel Rahim, M., Suddek, G.M. Anti-apoptotic effect of vinpocetine on cisplatin-induced hepatotoxicity in mice: The role of Annexin-V, Caspase-3, and Bax. Journal of Biochemical and Molecular Toxicology, 2020, 34(10), e22555. https://doi.org/10.1002/jbt.22555
  • Abdelhamid, A.M., Elsheakh, A.R., Abdelaziz, R.R., Suddek, G.M. Empagliflozin ameliorates ethanol-induced liver injury by modulating NF-κB/Nrf-2/PPAR-γ interplay in mice. Life Sciences, 2020, 256, 117908. https://doi.org/10.1016/j.lfs.2020.117908
  • Amin, F.M., Abdelaziz, R.R., Hamed, M.F., Nader, M.A., Shehatou, G.S.G. Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway. Life Sciences, 2020, 256, 117887. https://doi.org/10.1016/j.lfs.2020.117887
  • Abdallah, H.M., El-Agamy, D.S., Ibrahim, S.R.M., ...Safo, M.K., Malebari, A.M. Euphorbia cuneata represses LPS-induced acute lung injury in mice via its antioxidative and anti-inflammatory activities. Plants, 2020, 9(11), pp. 1–14, 1620. https://doi.org/10.3390/plants9111620
  • Ahmed, I., Elkablawy, M.A., El-Agamy, D.S., Bazarbay, A.A., Ahmed, N. Carvedilol safeguards against aspirin-induced gastric damage in rats. Human and Experimental Toxicology, 2020, 39(9), pp. 1257–1267. https://doi.org/10.1177/0960327120918306
  • Ahmed, N., El-Agamy, D.S., Mohammed, G.A., ...Elkablawy, M., Ibrahim, S.R.M. Suppression of LPS-Induced Hepato- and Cardiotoxic Effects by Pulicaria petiolaris via NF-κB Dependent Mechanism. Cardiovascular Toxicology, 2020, 20(2), pp. 121–129. https://doi.org/10.1007/s12012-019-09539-4
  • El-Agamy, D.S., Mohamed, G.A., Ahmed, N., .Mohamed, S.G.A., Ibrahim, S.R.M. Protective anti-inflammatory activity of tovophyllin A against acute lung injury and its potential cytotoxicity to epithelial lung and breast carcinomas. Inflammopharmacology, 2020, 28(1), pp. 153–163. https://doi.org/10.1007/s10787-019-00609-1
  • N Aljuhani, RS Ismail, MS El-Awady, MH Hassan. Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis. Acta Pharmaceutica, 2020, 70 (4), 515-525. https://doi.org/10.2478/acph-2020-0033
  • RS Ismail, MS El-Awady, MH Hassan. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology, 2020, 1-11. https://doi.org/10.1007/s00210-020-01823-3
  • MA Saleh, SA Antar, RM Hazem, MF El-Azab. Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways. Pharmaceuticals, 2020, 13 (11), 348. https://doi.org/10.3390/ph13110348
  • JK Prinsen, PJ Kannankeril, TN Sidorova, LV Yermalitskaya, O Boutaud. Highly reactive isolevuglandins promote atrial fibrillation caused by hypertension. Basic to Translational Science, 2020, 5 (6), 602-615. https://doi.org/10.1016/j.jacbts.2020.04.004
  • M Saber-Ayad, MA Saleh, E Abu-Gharbieh. The rationale for potential pharmacotherapy of COVID-19. Pharmaceuticals, 2020, 13 (5), 96. https://doi.org/10.3390/ph13050096
  • ME Shaker, HAM Gomaa, KS Alharbi, MM Al-Sanea, ME El-Mesery. Inhibition of Bruton tyrosine kinase by acalabrutinib dampens lipopolysaccharide/galactosamine-induced hepatic damage‏. Biomedicine & Pharmacotherapy, 2020, 131, 110736‏. https://doi.org/10.1016/j.biopha.2020.110736
  • M El-Mesery, MA Anany, SH Hazem, ME Shaker. The NEDD8-activating enzyme inhibition with MLN4924 sensitizes human cancer cells of different origins to apoptosis and necroptosis‏. Archives of Biochemistry and Biophysics, 2020, 691, 108513‏. https://doi.org/10.1016/j.abb.2020.108513
  • ME Shaker, AA Shaaban, MM El-Shafey, ME El-Mesery . The selective c-Met inhibitor capmatinib offsets cisplatin-nephrotoxicity and doxorubicin-cardiotoxicity and improves their anticancer efficacies‏. Toxicology and applied pharmacology, 2020, 398, 115018‏. https://doi.org/10.1016/j.taap.2020.115018
  • KM Saad, ME Shaker, AA Shaaban, RS Abdelrahman, E Said. The c-Met inhibitor capmatinib alleviates acetaminophen-induced hepatotoxicity‏. International immunopharmacology, 2020, 81, 106292.‏ https://doi.org/10.1016/j.intimp.2020.106292
  • AMA 2. Al-Sanea MM, Parambi DGT, Shaker ME, Elsherif HAM, Elshemy HAH, Bakr. Design, Synthesis, and In Vitro Cytotoxic Activity of Certain2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl]acetamide Derivatives.‏ Russian Journal of Organic Chemistry, 2020, 56 (3), 514-520. http://dx.doi.org/10.1134/S1070428020030239
  • MG Helal, YA Samra. Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice. Journal of biochemical and molecular toxicology, 2020, 34 (12), e22447. https://doi.org/10.1002/jbt.22447
  • MG Helal, E Said. Tranilast attenuates methotrexate‐induced renal and hepatic toxicities: Role of apoptosis‐induced tissue proliferation. Journal of biochemical and molecular toxicology, 2020, 34 (5), e22466. https://doi.org/10.1002/jbt.22466
  • YA Samra, MF Hamed, AR El‐Sheakh. Hepatoprotective effect of allicin against acetaminophen‐induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration. Journal of Biochemical and Molecular Toxicology, 2020, e22470. https://doi.org/10.1002/jbt.22470
  • EE El Naggar, EA Mohamed, TM Borg, AR El-Sheakh, MF Hamed. Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits. Drug Design, Development and Therapy, 2020, 14, 677. https://doi.org/10.2147/DDDT.S218357
  • Alzahrani, S., Ajwah, S.M., Alsharif, S.Y., ...Al-Shabrawey, M., Elsherbiny, N.M. Isoliquiritigenin downregulates miR-195 and attenuates oxidative stress and inflammation in STZ-induced retinal injury. Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 393(12), pp. 2375–2385. https://doi.org/10.1007/s00210-020-01948-5
  • Sharawy, M.H., Serrya, M.S. Pirfenidone attenuates gentamicin-induced acute kidney injury by inhibiting inflammasome-dependent NLRP3 pathway in rats. Life Sciences, 2020, 260, 118454. https://doi.org/10.1016/j.lfs.2020.118454
  • Qandeel, N.A., El-Damasy, A.K., Sharawy, M.H., Bayomi, S.M., El-Gohary, N.S. Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives. Bioorganic Chemistry, 2020, 102, 103890. https://doi.org/10.1016/j.bioorg.2020.103890
  • Makled, M.N., El-Kashef, D.H. Saroglitazar attenuates renal fibrosis induced by unilateral ureteral obstruction via inhibiting TGF-β/Smad signaling pathway. Life Sciences, 2020, 253, 117729. https://doi.org/10.1016/j.lfs.2020.117729
  • El-Kashef, D.H., Abdelrahman, R.S. Montelukast ameliorates Concanavalin A-induced autoimmune hepatitis in mice via inhibiting TNF-α/JNK signaling pathway. Toxicology and Applied Pharmacology, 2020, 393, 114931. https://doi.org/10.1016/j.taap.2020.114931
  • Amen, Y., Sherif, A.E., Shawky, N.M., ...Wink, M., Sobeh, M. Grape-leaf extract attenuates alcohol-induced liver injury via interference with Nf-κB signaling pathway. Biomolecules, 2020, 10(4), 558.  https://doi.org/10.3390/biom10040558
  • Shawky, N.M., Patil, C.N., Dalmasso, C., Drummond, H., Reckelhoff, J.F. Pregnancy Protects Hyperandrogenemic Female Rats from Postmenopausal Hypertension. Hypertension, 2020, pp. 943–952. https://doi.org/10.1161/hypertensionaha.120.15504
  • Ali, D.E., Abdelrahman, R.S., El Gedaily, R.A., ...Meselhy, M.R., Abdelsattar, E. Evaluation of the anti-inflammatory and antioxidant activities of selected resin exudates. Tropical Journal of Natural Product Research, 2020, 4(7), pp. 255–261. https://doi.org/10.26538/tjnpr/v4i7.1
  • Abdelrahman, R.S., Abdelmageed, M.E. Renoprotective effect of celecoxib against gentamicin-induced nephrotoxicity through suppressing NFκB and caspase-3 signaling pathways in rats. Chemico-Biological Interactions, 2020, 315, 1088632020. https://doi.org/10.1016/j.cbi.2019.108863
  • Helal MG, El-Kashef DH. Krill oil alleviates oxidative stress, iron accumulation and fibrosis in the liver and spleen of iron-overload rats. EnvironSci Pollut Res Int. 2020; 27(4):3950-3961. https://doi.org/10.1007/s11356-019-06983-1
  • Saad KM, Abdelrahman RS, Said E. Mechanistic perspective of protective effects of nilotinib against cisplatin-induced testicular injury in rats: Role of JNK/caspase-3 signaling inhibition. Environ Toxicol Pharmacol. 2020; 76:103334. https://doi.org/10.1016/j.etap.2020.103334
  • Kseibati MO, Shehatou GSG, Sharawy MH, Eladl AE, Salem HA. Nicorandil ameliorates bleomycin-induced pulmonary fibrosis in rats through modulating eNOS, iNOS, TXNIP and HIF-1α levels. Life Sci. 2020; 246:117423. https://doi.org/10.1016/j.lfs.2020.117423
  • Elsherbiny NM, Said E, Atef H, Zaitone SA. Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression. Chem Biol Interact. 2020; 315:108897. https://doi.org/10.1016/j.cbi.2019.108897
  • El-Far YM, Elsherbiny NM, El-Shafey M, Said E. The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats. Environ Toxicol Pharmacol. 2020; 79:103433. https://doi.org/10.1016/j.etap.2020.103433
  • Ashry NA, Abdеlaziz RR, Suddеk GM. The potential effect of imatinib against hypercholesterolemia induced atherosclerosis, endothelial dysfunction and hepatic injury in rabbits. Life Sci. 2020; 243:117275. https://doi.org/10.1016/j.lfs.2020.117275
  • Serrya MS, Zaghloul MS. Mycophenolate mofetil attenuates concanavalin A-induced acute liver injury through modulation of TLR4/NF-κB and Nrf2/HO-1 pathways. Pharmacol Rep. 2020; 72(4):945-955. https://doi.org/10.1007/s43440-019-00055-4

 

 

 

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شارع الجمهورية - المنصورة - محافظة الدقهلية

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  vice.dean-pharmacy@mans.edu.eg

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