Drug repurposing

Drug repurposing: Drug repurposing (also referred to as drug repositioning), the process of finding new uses of existing drugs, has been gaining popularity in recent years. Research studies in clinical practice involves drug repurposing of ‘old’ drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de‑risked compounds, with potentially lower overall development costs and shorter development timelines. With the successful clinical introduction of a number of non-cancer drugs for cancer treatment, drug repositioning now became a powerful alternative strategy to discover and develop novel anticancer drug candidates from the existing drug space.

Examples of department work within this research interest:

Abdallah MS, Ramadan AN, Omara‐Reda H, Mansour NO, Elsokary MA, Elsawah HK, Zaki SA, Mansour HE, Mosalam EM. Double‐blind, randomized, placebo‐controlled pilot study of the phosphodiesterase‐3 inhibitor cilostazol as an adjunctive to antidepressants in patients with major depressive disorder. CNS Neuroscience & Therapeutics. 2021 Dec;27(12):1540. DOI: 10.1111/cns.13731

Eltamalawy MM, Soliman MM, Omara AF, Rashad A, Ibrahim OM and El-Shishtawy MM. Efficacy and Safety of Neostigmine Adjunctive Therapy in Patients with Sepsis or Septic Shock: A Randomized Controlled Trial. Frontiers in pharmacology. 2022. DOI: 10.3389/fphar.2022.855764