15 December 2025 | Online.

We are excited to announce that BioThrust will join the Stem Cells & Extracellular Vesicles Educational Day as an official industrial partner.

BioThrust develops the ComfyCell™ platform — a new generation of bionic bioreactors designed for scalable cultivation of shear‑sensitive cells and EV production. During the event, BioThrust will share insights into bubble‑free bioreactor operation and how gentle, foam‑free gassing can support robust, scalable cell and EV manufacturing.

This partnership strengthens our international collaboration between HPNE Egypt, Elbeltagy Therapeutics, and leading technology providers to accelerate EV‑based translation and manufacturing capacity.

Learn more about BioThrust: https://www.biothrust.com/

Explore the ComfyCell™ platform: https://www.biothrust.com/product

We look forward to a day of deep scientific discussion, practical bioprocessing lessons, and future‑shaping collaborations!

Technical Announcement — BioThrust to Contribute Bioreactor Scale‑Up Expertise for Sensitive Cells & EV Manufacturing

We are pleased to confirm BioThrust as an industrial partner for the Stem Cells & Extracellular Vesicles Educational Day. BioThrust is a Germany‑based biotechnology startup developing the ComfyCell™ platform, built around a Membrane Stirrer concept that combines mixing and gas transfer in a bubble‑free format to minimize shear stress and foaming.

Why BioThrust matters for EV translation

· Gentle, bubble‑free aeration supports cultivation of shear‑sensitive producer cells (e.g., MSCs, iPSCs, immune cells) while reducing foam‑related handling issues.

· High gas transfer enables stable operation without conventional sparging — supporting process intensification and more reproducible manufacturing conditions.

· ComfyCell™ can integrate with standard upstream workflows (batch, fed‑batch, and perfusion concepts), facilitating translation from lab runs to scalable production.

Our joint progress with ComfyCell™ (MSCs and other sensitive cells)

Within our collaboration, the ComfyCell™ platform is being used to advance cultivation conditions for MSCs and other sensitive cell types relevant to EV production. The focus is on establishing reproducible operating windows (mixing, oxygenation, and harvest routines) that protect cell health and support downstream EV isolation workflows. These learnings directly support the project goal of building a scalable, cost‑effective manufacturing pathway compatible with future GMP translation.