Publications of the Department of Pharmaceutical Organic Chemistry 2019

0d57f20faad2ba2ed8e45e0792dec669Abdelaziz, O.A., El Husseiny, W.M., Selim, K.B. and Eisa, H.M., 2019. Dihydrofolate reductase inhibition effect of 5-substituted pyrido [2, 3-d] pyrimidines: Synthesis, antitumor activity and molecular modeling study. Bioorganic Chemistry, 90, p.103076. https://www.sciencedirect.com/science/article/pii/S0045206819304493?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Elfeky, S., Sobahi, T., Gineinah, M.M. and Ahmed, N.S., 2019. Ultrasound one pot synthesis of fused quinazolinones and quinazolinediones, screening and molecular docking study as phosphodiesterase 7A inhibitors. Egyptian Journal of Chemistry, 62(8), pp.1451-1466. 10.21608/EJCHEM.2019.7130.1587

0d57f20faad2ba2ed8e45e0792dec669Al-Romaizan, A.N., Ahmed, N.S. and Elfeky, S.M., 2019. Design, Synthesis, and Biological Evaluation of Triazolyl-and Triazinyl-Quinazolinediones as Potential Antitumor Agents. Journal of Chemistry, 2019. https://doi.org/10.1155/2019/9104653

0d57f20faad2ba2ed8e45e0792dec669Born, A., Nichols, P.J., Henen, M.A., Chi, C.N., Strotz, D., Bayer, P., Tate, S.I., Peng, J.W. and Vögeli, B., 2019. Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery. Biomolecular NMR Assignments, 13(1), pp.85-89. https://link.springer.com/article/10.1007/s12104-018-9857-9

0d57f20faad2ba2ed8e45e0792dec669Abo-Elanwar, Y.A., Mostafa, A.S., El-Sayed, M.A. and Nasr, M.N., 2019. Synthesis and biological evaluation of new 2-(4-fluorophenyl) imidazol-5-ones as anticancer agents. Journal of Applied Pharmaceutical Science, 9(05), pp.1-11. https://www.japsonline.com/abstract.php?article_id=2903&sts=2

0d57f20faad2ba2ed8e45e0792dec669Zeidan, M.A., Mostafa, A.S., Gomaa, R.M., Abou-Zeid, L.A., El-Mesery, M., Magda, A.A. and Selim, K.B., 2019. Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors. European journal of medicinal chemistry, 168, pp.315-329. https://www.sciencedirect.com/science/article/pii/S0223523419301643?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Hamdi, A., Laurent, M.Y., Hémon-Ribaud, A., Mostafa, A.S., Massoud, M.A., Selim, K.B. and Dujardin, G., 2019. 1, 3-Dipolar cycloaddition of vinyloxy quinolines with α-alkoxy carbonyl aldonitrones or cyclic surrogates: A comparative study for an asymmetric access to trans 4-quinolinoxy oxaprolines. Tetrahedron, 75(3), pp.429-440. https://www.sciencedirect.com/science/article/pii/S0040402018314844?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Mostafa, A.S., Gomaa, R.M. and Elmorsy, M.A., 2019. Design and synthesis of 2‐phenyl benzimidazole derivatives as VEGFR‐2 inhibitors with anti‐breast cancer activity. Chemical Biology & Drug Design, 93(4), pp.454-463. https://onlinelibrary.wiley.com/doi/10.1111/cbdd.13433

0d57f20faad2ba2ed8e45e0792dec669Mostafa, A.S., Bayoumi, W.A., El-Mesery, M. and Elgaml, A., 2019. Molecular Design and Synthesis of New 3, 4-Dihydropyrimidin-2 (1H)-ones as Potential Anticancer Agents with VEGFR-2 Inhibiting Activity. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 19(3), pp.310-322. http://www.eurekaselect.com/article/91762

0d57f20faad2ba2ed8e45e0792dec669Elkamhawy, A., youn Kim, N., Hassan, A.H., Park, J.E., Yang, J.E., Oh, K.S., Lee, B.H., Lee, M.Y., Shin, K.J., Lee, K.T. and Hur, W., 2018. Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators. European Journal of Medicinal Chemistry, 157, pp.691-704.https://www.sciencedirect.com/science/article/pii/S0223523418306780?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Elkamhawy, A., Park, J.E., Hassan, A.H., Pae, A.N., Lee, J., Paik, S., Park, B.G. and Roh, E.J., 2018. Pyrazinyl ureas revisited: 1-(3-(Benzyloxy) pyrazin-2-yl)-3-(3, 4-dichlorophenyl) urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease. European journal of medicinal chemistry, 157, pp.268-278.https://www.sciencedirect.com/science/article/pii/S0223523418306330?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Al-Sanea, M.M., Elkamhawy, A., Paik, S., Bua, S., Ha Lee, S., Abdelgawad, M.A., Roh, E.J., Eldehna, W.M. and Supuran, C.T., 2019. Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino) benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), pp.1457-1464. https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1652282

0d57f20faad2ba2ed8e45e0792dec669Simone, R., Balendra, R., Moens, T.G., Preza, E., Wilson, K.M., Heslegrave, A., Woodling, N.S., Niccoli, T., Gilbert‐Jaramillo, J., Abdelkarim, S. and Clayton, E.L., 2018. G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. EMBO molecular medicine, 10(1), pp.22-31. https://www.embopress.org/doi/full/10.15252/emmm.201707850

0d57f20faad2ba2ed8e45e0792dec669Othman, D.I., Selim, K.B., Magda, A.A., Tantawy, A.S., Amen, Y., Shimizu, K., Okauchi, T. and Kitamura, M., 2019. Design, synthesis and anticancer evaluation of new substituted thiophene-quinoline derivatives. Bioorganic & Medicinal Chemistry, 27(19), p.115026.https://www.sciencedirect.com/science/article/pii/S0968089619311496?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Ahmed, E.M., Sarhan, A.E., El-Naggar, D.H., Khattab, R.R., El-Naggar, M., El-Messery, S.M., Hassan, G.S., Mounier, M.M., Mahmoud, K., Ali, N.I. and Mahrous, K.F., 2019. Towards breast cancer targeting: Synthesis of tetrahydroindolocarbazoles, antibreast cancer evaluation, uPA inhibition, molecular genetic and molecular modelling studies. Bioorganic Chemistry, 93, p.103332. https://www.sciencedirect.com/science/article/pii/S0045206819303669?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Alrohily, W.D., Habib, M.E., El-Messery, S.M., Alqurshi, A., El-Subbagh, H. and Habib, E.S.E., 2019. Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors. Microbial pathogenesis, 136, p.103674. https://www.sciencedirect.com/science/article/pii/S0882401019307132?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Omran, D.M., Ghaly, M.A., El-Messery, S.M., Badria, F.A., Abdel-Latif, E. and Shehata, I.A., 2019. Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies. Bioorganic Chemistry, 88, p.102917. https://www.sciencedirect.com/science/article/pii/S0045206819301725?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669El-Sharief, M.A.S., Abbas, S.Y., El-Sharief, A.M.S., Sabry, N.M., Moussa, Z., El-Messery, S.M., Elsheakh, A.R., Hassan, G.S. and El Sayed, M.T., 2019. 5-Thioxoimidazolidine-2-one derivatives: Synthesis, anti-inflammatory activity, analgesic activity, COX inhibition assay and molecular modelling study. Bioorganic Chemistry, 87, pp.679-687. https://www.sciencedirect.com/science/article/pii/S0045206818314330?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Ayman, M., El-Messery, S.M., Habib, E.E., Al-Rashood, S.T., Almehizia, A.A., Alkahtani, H.M. and Hassan, G.S., 2019. Targeting microbial resistance: Synthesis, antibacterial evaluation, DNA binding and modeling study of new chalcone-based dithiocarbamate derivatives. Bioorganic Chemistry, 85, pp.282-292. https://www.sciencedirect.com/science/article/pii/S004520681830751X?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Abdelaziz, O.A., El Husseiny, W.M., Selim, K.B. and Eisa, H.M., 2019. Dihydrofolate reductase inhibition effect of 5-substituted pyrido [2, 3-d] pyrimidines: Synthesis, antitumor activity and molecular modeling study. Bioorganic Chemistry, 90, p.103076. https://doi.org/10.1016/j.bioorg.2019.103076

0d57f20faad2ba2ed8e45e0792dec669Elfeky, S., Sobahi, T., Gineinah, M.M. and Ahmed, N.S., 2019. Ultrasound one pot synthesis of fused quinazolinones and quinazolinediones, screening and molecular docking study as phosphodiesterase 7A inhibitors. Egyptian Journal of Chemistry, 62(8), pp.1451-1466. 10.21608/EJCHEM.2019.7130.1587

0d57f20faad2ba2ed8e45e0792dec669Al-Romaizan, A.N., Ahmed, N.S. and Elfeky, S.M., 2019. Design, Synthesis, and Biological Evaluation of Triazolyl-and Triazinyl-Quinazolinediones as Potential Antitumor Agents. Journal of Chemistry, 2019. https://doi.org/10.1155/2019/9104653

0d57f20faad2ba2ed8e45e0792dec669Born, A., Nichols, P.J., Henen, M.A., Chi, C.N., Strotz, D., Bayer, P., Tate, S.I., Peng, J.W. and Vögeli, B., 2019. Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery. Biomolecular NMR Assignments, 13(1), pp.85-89. https://doi.org/10.1007/s12104-018-9857-9

0d57f20faad2ba2ed8e45e0792dec669Rania, M.G., Mohamed, A.M. and Hassan, M.E., Design, Synthesis and Molecular Modeling of New 1, 3, 5-Triazine Derivatives as Anticancer Agents.

 

0d57f20faad2ba2ed8e45e0792dec669Depauw, S., Lambert, M., Jambon, S., Paul, A., Peixoto, P., Nhili, R., Marongiu, L., Figeac, M., Dassi, C., Paul-Constant, C. and Billoré, B., 2019. Heterocyclic diamidine DNA ligands as HOXA9 transcription factor inhibitors: Design, molecular evaluation, and cellular consequences in a HOXA9-dependant leukemia cell model. Journal of medicinal chemistry, 62(3), pp.1306-1329.https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01448

0d57f20faad2ba2ed8e45e0792dec669Erlitzki, N., Farahat, A.A., Kumar, A., Boykin, D.W. and Poon, G.M., 2019. DNA recognition by linear indole-biphenyl DNA minor groove ligands. Biophysical Chemistry, 245, pp.6-16. https://www.sciencedirect.com/science/article/pii/S0301462218303132?via%3Dihub

0d57f20faad2ba2ed8e45e0792dec669Mizuta, R., Devos, J.M., Narayanan, T., Oliva, M., Gray, M., Webster, J., Ling, W.L., Round, A., Munnur, D., Mossou, E. and Farahat, A., 2019, August. Hierarchical Nanotube Self‐Assembly of DNA Minor Groove‐Binding Ligand DB921 via Alkali Halide Triggering. In Macromolecular Symposia (Vol. 386, No. 1, p. 1800243). https://onlinelibrary.wiley.com/doi/10.1002/masy.201800243

0d57f20faad2ba2ed8e45e0792dec669Nam, Y., Hwang, D., Kim, N., Seo, H.S., Selim, K.B. and Sim, T., 2019. Identification of 1 H-pyrazolo [3, 4-b] pyridine derivatives as potent ALK-L1196M inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), pp.1426-1438. https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1639694

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