Structural information pertaining to the interactions between biological macromolecules and ligands is of potential significance for understanding of molecular mechanisms in key biological processes. Recently, nuclear magnetic resonance (NMR) spectroscopic techniques has come of age and has widened its scope to characterize binding interactions of small molecules with biological macromolecules especially, proteins.

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Nashaat, S., Henen, M.A., El-Messery, S.M. and Eisa, H., 2020. Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer. Bioorganic & Medicinal Chemistry, 28(11), p.115495. https://www.sciencedirect.com/science/article/pii/S0968089620303163?via%3Dihub