Chemistry and biology of natural products including: all methods of extraction of natural products; chromatographic isolation and identification of the natural products using different types of chromatography such as VLC, HPLC, TLC, preparative and analytical HPLC, gel filtration chromatography, electrophoresis chromatography; structural elucidation of the isolated secondary metabolites using 1D and 2D NMR, UV, IR, optical rotation, LCMS, HRMS, elemental analysis, GCMS, X-ray crystallography and circular dichroism (CD); stereochemistry of natural products; biosynthesis of natural products, feeding experiments using 13C labeled acetate units; semisynthesis; biological assays such as antimicrobial, antioxidant, cytotoxicity, assays towards protease enzymes, assays towards cannabinoid receptors; PCR, and gel electrophoresis; biotransformation; biocatalysis; plant tissue culture; metabolomics (beginner).

Selected Publications:

1. Elsebai M. F., (First & Corresponding Author), “Amberboin and lipidiol: X-ray crystalographic data, absolute configuration and inhibition of cholinesterase” Phytochemistry Letters, (2018) 27, 44-48. https://doi.org/10.1016/j.phytol.2018.06.023, Impact Factor: 1.4.

2. Elsebai M. F. et al (First & Corresponding Author), "New Bioactive Chlorinated Cyclopentene Derivatives from the Marine-Derived Fungus Phoma sp. isolated from the sponge Ectyplasia perox", Medicinal Chemistry Research (2018), doi: 10.1007/s00044-018-2201-1, Impact Factor: 1.3.

3. Elsebai M. F. et al (co-author), “Metabolome based classification of artichoke leaf: A prospect for phyto-equivalency of its different leaf origins and commercial preparations”, doi.org/10.1016/j.jpba.2018.05.046, Journal of Pharmaceutical and Biomedical Analysis, 158, 151–159, (2018). Impact Factor: 3.2

4. Elsebai M. F. et al, Journal of Pharmaceutical and Biomedical Analysis (2017), “Metabolites profiling reveals for antimicrobial compositional differences and action mechanism in the tooth brushing stick “miswak” Salvadora persica”, 133, 30, 32–40, doi: 10.1016/j.jpba.2016.11.018). Impact Factor: 3.3 – Q1 Journal.

5. Elsebai M. F., et al., (First Author), Food & Function (2016) “The Wild Egyptian Artichoke as a Promising Functional Food for the Treatment of Hepatitis C Virus as Revealed via UPLC-MS and Clinical Trial”, 7, 7, 3006-3016. Impact Factor: 3.3 – Q1 Journal.

6. Elsebai M. F., et al., (First Author), Journal of Virology (2016) "Pan-genotypic hepatitis C virus inhibition by natural products derived from the wild Egyptian artichoke", 90, 4, 1918-1930. Impact Factor: 4.7 – Q1 Journal.

7. Elsebai M. F. et al, (First & Corresponding Author), Frontiers in Pharmacology (2016), “Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential as an Anti-Hepatitis C Virus Agent”, 7, 12, Article 472, doi: 10.3389/fphar.2016.00472. Impact Factor: 4.5 – Q1 Journal.

8. Elsebai M. F., et al., (First & Corresponding Author), Molecules (2016) “Unusual phenalenone derivatives from the marine-derived fungus Coniothyrium cereale”, 21, 2, 1-13. Impact Factor: 2.9 – Q2 Journal.

9. Elsebai M. F., and Ghabbour H. A., (First & Corresponding Author), Tetrahedron Letters (2016) “Isocoumarin Derivatives from the Marine-Derived Fungus Phoma sp. 135”, 57, 354-356. Impact Factor: 2.4 – Q2 Journal.

10. Elsebai M. F. (co-author) et al., Industrial Crops and Products (2016) “Chemical composition and in vitro antimicrobial, insecticidal and antioxidant activities of the essential oils of Mentha pulegium L. and Mentha rotundifolia (L.) Huds growing in Algeria", 88, 96-105. Impact Factor: 3.5 – Q1 Journal.

11. Elsebai M. F., et al., (First & Corresponding Author), Natural Product Reports (2014) “Fungal phenalenones: chemistry, biology, biosynthesis and phylogeny”, 31, 628-645. Impact Factor: 11.0 – Q1 Journal.

12. Book chapter: LEGRAVE Nathalie, Mahmoud F. Elsebai, MEHIRI Mohamed, AMADE Philippe, "Marine Polyacetylenes: Distribution, Biological Properties, and Synthesis" of the book "Studies in Natural Products Chemistry, Atta-ur-Rahman, FRS", (2015), Copyright © 2015 Elsevier, volume 45, pages 251-292.

13. Book chapter: (First Author), Mahmoud F. Elsebai, Mysore V. Tejesvi, Anna Maria Pirttilä, "Endophytes as a novel source of bioactive new structures" of the book "Advances in Endophytic Research, V.C. Verma and A.C. Gange (eds.)", (2014), DOI 10.1007/978-81-322-1575-2_10, ©Springer India 2014, pages 191-202.

14. Elsebai M. F., et al., (First Author), Steroids (2013) “Caught between triterpene- and steroid-metabolism: 4α-carboxylic pregnane-derivative from the marine alga-derived fungus Phaeosphaeria spartinae", 78(9), 880-883. Impact Factor: 2.7 – Q3 Journal.

15. Elsebai M. F., et al., (First Author), European Journal of Organic Chemistry (2012), “Polyketide skeletons from the marine alga-derived fungus Coniothyrium cereale", 6197–6203. Impact Factor: 3.2– Q2 Journal.

16. Elsebai M. F., et al., (First Author), ACS Medicinal Chemistry Letters (2011), “Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum”, 2, 866-869. Impact Factor: 3.8 – Q1 Journal.

17. Elsebai M. F., et al., (First Author), Journal of Natural Products (2011), “HLE-inhibitory alkaloids with a polyketide skeleton from the marine-derived fungus Coniothyrium cereale”, 74, 10, 2282-2285. Impact Factor: 3.9 – Q1 Journal.

18. Elsebai M. F., et al., (First Author), Organic & Biomolecular Chemistry (2011), “Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale”, 9, 3, 802-808. Impact Factor: 3.6 – Q1 Journal.

Patents:

Patent application: (2015), Egyptian patent office, WO 2016/169573, titled "Potent and Broad Spectrum Compounds against all genotypes of Hepatitis C Virus (HCV)".

Patent application: (2014), European Patent Application, WO2014008901(A2), titled: "The use of Artichoke for eradication of Hepatitis C virus (HCV)".