Publications of the Department of Pharmaceutical Organic Chemistry 2022

a597d13f21b81e9e2baf9ca667dba121Nada, H., Elkamhawy, A., Abdellattif, M.H., Angeli, A., Lee, C.H., Supuran, C.T. and Lee, K., 2022. 4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies. Journal of enzyme inhibition and medicinal chemistry37(1), pp.994-1004. https://doi.org/10.1080/14756366.2022.2055553

a597d13f21b81e9e2baf9ca667dba121Elkamhawy, A., Woo, J., Nada, H., Angeli, A., Bedair, T.M., Supuran, C.T. and Lee, K., 2022. Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies. International journal of molecular sciences23(5), p.2540. https://doi.org/10.3390/ijms23052540

a597d13f21b81e9e2baf9ca667dba121Mansour, B., Bayoumi, W.A., El‐Sayed, M.A., Abouzeid, L.A. and Massoud, M.A., 2022. In vitro cytotoxicity and docking study of novel symmetric and asymmetric dihydropyridines and pyridines as EGFR tyrosine kinase inhibitors. Chemical Biology & Drug Design. https://doi.org/10.1111/cbdd.14058

a597d13f21b81e9e2baf9ca667dba121Ornelas, A., Wang, R.X., Welch, N., Henen, M.A., Vögeli, B. and Colgan, S.P., 2022. Butyrate Analogues Mimicking Hypoxia by the Chemical Stabilization of Hypoxia Inducible Factor (HIF). The FASEB Journal36. https://doi.org/10.1096/fasebj.2022.36.S1.R5332

a597d13f21b81e9e2baf9ca667dba121Paul, A., Farahat, A.A., Boykin, D.W. and Wilson, W.D., 2022. Thermodynamic Factors That Drive Sequence-Specific DNA Binding of Designed, Synthetic Minor Groove Binding Agents. Life12(5), p.681. https://doi.org/10.3390/life12050681

a597d13f21b81e9e2baf9ca667dba121Boykin, D.W., Kyle, D.E., Rice, C.A. and Farahat, A.A., University of Georgia Research Foundation Inc UGARF, University of South Florida and Georgia State University Research Foundation Inc, 2022. Treatment of acanthamoeba or balamuthia trophozoites and/or cysts. U.S. Patent Application 17/286,058.

a597d13f21b81e9e2baf9ca667dba121Al-Wahaibi, L.H., Asokan, K.V., Al-Shaalan, N.H., Tawfik, S.S., Hassan, H.M., El-Emam, A.A., Percino, M.J. and Thamotharan, S., 2022. Supramolecular Self-Assembly Mediated by Multiple Hydrogen Bonds and the Importance of C–S··· N Chalcogen Bonds in N′-(Adamantan-2-ylidene) hydrazide Derivatives. ACS omega7(12), pp.10608-10621. https://doi.org/10.1021/acsomega.2c00159

a597d13f21b81e9e2baf9ca667dba121Othman, D.I., Hamdi, A., Abdel-Aziz, M.M. and Elfeky, S.M., 2022. Novel 2-arylthiazolidin-4-one-thiazole hybrids with potent activity against Mycobacterium tuberculosis. Bioorganic Chemistry124, p.105809. https://doi.org/10.1016/j.bioorg.2022.105809

a597d13f21b81e9e2baf9ca667dba121Hamdi, A., El-Shafey, H.W., Othman, D.I., El-Azab, A.S., AlSaif, N.A. and Alaa, A.M., 2022. Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies. Bioorganic Chemistry122, p.105710. https://doi.org/10.1016/j.bioorg.2022.105710

a597d13f21b81e9e2baf9ca667dba121Almatary, A.M., El Husseiny, W.M., Selim, K.B. and Eisa, H.M., 2022. Nitroimidazole-sulfonamides as carbonic anhydrase IX and XII inhibitors targeting tumor hypoxia: Design, synthesis, molecular docking and molecular dynamics simulation. Journal of Molecular Structure, p.133260. https://doi.org/10.1016/j.molstruc.2022.133260

a597d13f21b81e9e2baf9ca667dba121Gouda, N.A., Elkamhawy, A. and Cho, J., 2022. Emerging Therapeutic Strategies for Parkinson’s Disease and Future Prospects: A 2021 Update. Biomedicines, 10(2), p.371. https://www.mdpi.com/2227-9059/10/2/371

a597d13f21b81e9e2baf9ca667dba121Paukovich, N., Henen, M.A., Hussain, A., Issaian, A., Sikela, J.M., Hansen, K.C. and Vögeli, B., 2022. Solution NMR backbone assignments of disordered Olduvai protein domain CON1 employing Hα-detected experiments. Biomolecular NMR Assignments, pp.1-7. https://link.springer.com/article/10.1007/s12104-022-10068-5

a597d13f21b81e9e2baf9ca667dba121De Silva, S.M., Sood, S., Dhiman, A., Mercedes, K.F., Henen, M.A., Vögeli, B., Dykhuizen, E.C. and Musselman, C.A., 2022. PBRM1 BD2 and BD4 associate with RNA to facilitate chromatin association. https://www.biorxiv.org/content/10.1101/2022.02.07.479474v1

a597d13f21b81e9e2baf9ca667dba121Nada, H., Lee, K., Gotina, L., Pae, A.N. and Elkamhawy, A., 2022. Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches. Computers in biology and medicine, p.105217. https://www.sciencedirect.com/science/article/pii/S0010482522000099?via%3Dihub

a597d13f21b81e9e2baf9ca667dba121Gomaa, R.M., El-Sayed, M.A. and Selim, K.B., 2022. Synthesis, Antitumor Activities and Molecular Modelling of 4-Anilinoquinazoline Derivatives as EGFR-TK Inhibitors. https://www.researchsquare.com/article/rs-1222057/v1

a597d13f21b81e9e2baf9ca667dba121Elfeky, S.M., Almehmadi, S.J. and Tawfik, S.S., 2022. Synthesis, in-silico, and in-vitro study of novel chloro methylquinazolinones as PI3K-δ inhibitors, cytotoxic agents. Arabian Journal of Chemistry, 15(2), p.103614. https://www.sciencedirect.com/science/article/pii/S1878535221006298?via%3Dihub

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