Publications of the Department of Pharmaceutical Organic Chemistry 2022
Nada, H., Elkamhawy, A., Abdellattif, M.H., Angeli, A., Lee, C.H., Supuran, C.T. and Lee, K., 2022. 4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies. Journal of enzyme inhibition and medicinal chemistry, 37(1), pp.994-1004. https://doi.org/10.1080/14756366.2022.2055553
Elkamhawy, A., Woo, J., Nada, H., Angeli, A., Bedair, T.M., Supuran, C.T. and Lee, K., 2022. Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies. International journal of molecular sciences, 23(5), p.2540. https://doi.org/10.3390/ijms23052540
Mansour, B., Bayoumi, W.A., El‐Sayed, M.A., Abouzeid, L.A. and Massoud, M.A., 2022. In vitro cytotoxicity and docking study of novel symmetric and asymmetric dihydropyridines and pyridines as EGFR tyrosine kinase inhibitors. Chemical Biology & Drug Design. https://doi.org/10.1111/cbdd.14058
Ornelas, A., Wang, R.X., Welch, N., Henen, M.A., Vögeli, B. and Colgan, S.P., 2022. Butyrate Analogues Mimicking Hypoxia by the Chemical Stabilization of Hypoxia Inducible Factor (HIF). The FASEB Journal, 36. https://doi.org/10.1096/fasebj.2022.36.S1.R5332
Paul, A., Farahat, A.A., Boykin, D.W. and Wilson, W.D., 2022. Thermodynamic Factors That Drive Sequence-Specific DNA Binding of Designed, Synthetic Minor Groove Binding Agents. Life, 12(5), p.681. https://doi.org/10.3390/life12050681
Boykin, D.W., Kyle, D.E., Rice, C.A. and Farahat, A.A., University of Georgia Research Foundation Inc UGARF, University of South Florida and Georgia State University Research Foundation Inc, 2022. Treatment of acanthamoeba or balamuthia trophozoites and/or cysts. U.S. Patent Application 17/286,058.
Al-Wahaibi, L.H., Asokan, K.V., Al-Shaalan, N.H., Tawfik, S.S., Hassan, H.M., El-Emam, A.A., Percino, M.J. and Thamotharan, S., 2022. Supramolecular Self-Assembly Mediated by Multiple Hydrogen Bonds and the Importance of C–S··· N Chalcogen Bonds in N′-(Adamantan-2-ylidene) hydrazide Derivatives. ACS omega, 7(12), pp.10608-10621. https://doi.org/10.1021/acsomega.2c00159
Othman, D.I., Hamdi, A., Abdel-Aziz, M.M. and Elfeky, S.M., 2022. Novel 2-arylthiazolidin-4-one-thiazole hybrids with potent activity against Mycobacterium tuberculosis. Bioorganic Chemistry, 124, p.105809. https://doi.org/10.1016/j.bioorg.2022.105809
Hamdi, A., El-Shafey, H.W., Othman, D.I., El-Azab, A.S., AlSaif, N.A. and Alaa, A.M., 2022. Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies. Bioorganic Chemistry, 122, p.105710. https://doi.org/10.1016/j.bioorg.2022.105710
Almatary, A.M., El Husseiny, W.M., Selim, K.B. and Eisa, H.M., 2022. Nitroimidazole-sulfonamides as carbonic anhydrase IX and XII inhibitors targeting tumor hypoxia: Design, synthesis, molecular docking and molecular dynamics simulation. Journal of Molecular Structure, p.133260. https://doi.org/10.1016/j.molstruc.2022.133260
Gouda, N.A., Elkamhawy, A. and Cho, J., 2022. Emerging Therapeutic Strategies for Parkinson’s Disease and Future Prospects: A 2021 Update. Biomedicines, 10(2), p.371. https://www.mdpi.com/2227-9059/10/2/371
Paukovich, N., Henen, M.A., Hussain, A., Issaian, A., Sikela, J.M., Hansen, K.C. and Vögeli, B., 2022. Solution NMR backbone assignments of disordered Olduvai protein domain CON1 employing Hα-detected experiments. Biomolecular NMR Assignments, pp.1-7. https://link.springer.com/article/10.1007/s12104-022-10068-5
De Silva, S.M., Sood, S., Dhiman, A., Mercedes, K.F., Henen, M.A., Vögeli, B., Dykhuizen, E.C. and Musselman, C.A., 2022. PBRM1 BD2 and BD4 associate with RNA to facilitate chromatin association. https://www.biorxiv.org/content/10.1101/2022.02.07.479474v1
Nada, H., Lee, K., Gotina, L., Pae, A.N. and Elkamhawy, A., 2022. Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches. Computers in biology and medicine, p.105217. https://www.sciencedirect.com/science/article/pii/S0010482522000099?via%3Dihub
Gomaa, R.M., El-Sayed, M.A. and Selim, K.B., 2022. Synthesis, Antitumor Activities and Molecular Modelling of 4-Anilinoquinazoline Derivatives as EGFR-TK Inhibitors. https://www.researchsquare.com/article/rs-1222057/v1
Elfeky, S.M., Almehmadi, S.J. and Tawfik, S.S., 2022. Synthesis, in-silico, and in-vitro study of novel chloro methylquinazolinones as PI3K-δ inhibitors, cytotoxic agents. Arabian Journal of Chemistry, 15(2), p.103614. https://www.sciencedirect.com/science/article/pii/S1878535221006298?via%3Dihub