Organic synthesis of medicinal and pharmaceutical agents

Organic synthesis involves strategies for making compounds from readily available starting materials by one or more steps. The heart of organic synthesis is designing synthetic routes to a molecule. A systematic approach for designing a synthetic route to a target molecule is to use an intellectual exercise called a retrosynthetic analysis, which can determine the reactions and starting materials needed.

 

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Related publications:

El Sayed, M.T., Sarhan, A.E., Ahmed, E., Khattab, R.R., Elnaggar, M., El‐Messery, S.M., Shaldam, M.A. and Hassan, G.S., 2020. Novel Pyruvate Kinase (PK) Inhibitors: New Target to Overcome Bacterial Resistance. ChemistrySelect, 5(11), pp.3445-3453. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202000043

Ewes, W.A., Elmorsy, M.A., El-Messery, S.M. and Nasr, M.N., 2020. Synthesis, biological evaluation and molecular modeling study of [1, 2, 4]-Triazolo [4, 3-c] quinazolines: New class of EGFR-TK inhibitors. Bioorganic & medicinal chemistry, 28(7), p.115373. https://www.sciencedirect.com/science/article/pii/S0968089620301693?via%3Dihub

 Nashaat, S., Henen, M.A., El-Messery, S.M. and Eisa, H., 2020. Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer. Bioorganic & Medicinal Chemistry, 28(11), p.115495. https://www.sciencedirect.com/science/article/pii/S0968089620303163?via%3Dihub

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