Pharmacology and toxicology Publications 2021

 

  • Makled, M.N., El-Awady, M.S., Abdel-Aziz, R.R., .Ammar, E.M., Gameil, N.M. Pomegranate extract ameliorates renal ischemia/reperfusion injury in rats via suppressing NF-κB pathway. Human and Experimental Toxicology, 2021, 40(12_suppl), pp. S573–S582. https://doi.org/10.1177/09603271211041998
  • Elsayed, M.S., Abu-Elsaad, N.M., Nader, M.A. The NLRP3 inhibitor dapansutrile attenuates folic acid induced nephrotoxicity via inhibiting inflammasome/caspase-1/IL axis and regulating autophagy/proliferation. Life Sciences, 2021, 285, 119974. https://doi.org/10.1016/j.lfs.2021.119974
  • Ibrahim, S.R.M., Altyar, A.E., Sindi, I.A., ...Mohamed, S.G.A., Mohamed, G.A. Kirenol: A promising bioactive metabolite from siegesbeckia species: A detailed review. Journal of Ethnopharmacology, 2021, 281, 114552. https://doi.org/10.1016/j.jep.2021.114552
  • Mohamed, G.A., Ibrahim, S.R.M., El-Agamy, D.S., ...Koshak, A.E., Elhady, S.S. Terretonin as a new protective agent against sepsis-induced acute lung injury: Impact on SIRT1/Nrf2/NF-κBp65/NLRP3 signaling. Biology, 2021, 10(11), 1219. https://doi.org/10.3390/biology10111219
  • Shaker, M.E., Eisa, N.H., Elgaml, A., ...El-Mowafy, M., El-Mesery, M. Ingestion of mannose ameliorates thioacetamide-induced intrahepatic oxidative stress, inflammation and fibrosis in rats. Life Sciences, 2021, 286, 120040. https://doi.org/10.1016/j.lfs.2021.120040
  • El-Sherbiny, M., Fahmy, E.K., Eisa, N.H., ...Elsherbiny, N.M., Ghoneim, F.M. Nanogold particles suppresses 5-flurouracil-induced renal injury: An insight into the modulation of nrf-2 and its downstream targets, ho-1 and γ-gcs. Molecules, 2021, 26(24),768.https://www.mdpi.com/1420-3049/26/24/7684
  • El-Sherbiny, M., Eisa, N.H., Abo El-Magd, N.F., ...Said, E., Khodir, A.E. Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into TLR4/NF-kB/caspase signalling modulation. Environmental Toxicology and Pharmacology, 2021, 88, 103750. https://doi.org/10.1016/j.etap.2021.103750
  • Sharawy, M.H., El-Kashef, D.H., Shaaban, A.A., El-Agamy, D.S. Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition. International Immunopharmacology, 2021, 100, 108088. https://doi.org/10.1016/j.intimp.2021.108088
  • Abd Elhameed, A.G., Helal, M.G., Said, E., Salem, H.A. Saxagliptin defers thioacetamide-induced hepatocarcinogenesis in rats: A novel suppressive impact on Wnt/Hedgehog/Notch1 signaling. Environmental Toxicology and Pharmacology , 2021, 86, 103668. https://doi.org/10.1016/j.etap.2021.103668
  • Abdelmageed, M.E. Shehatou, G.S.G., Suddek, G.M., Salem, H.A. Protocatechuic acid improves hepatic insulin resistance and restores vascular oxidative status in type-2 diabetic rats. Environmental Toxicology and Pharmacology , 2021, 83, 103577. https://doi.org/10.1016/j.etap.2020.103577
  • Amer, A.E., Shehatou, G.S.G., El-Kashef, H.A., Nader, M.A., El-Sheakh, A.R. Flavocoxid Ameliorates Aortic Calcification Induced by Hypervitaminosis D3 and Nicotine in Rats Via Targeting TNF-α, IL-1β, iNOS, and Osteogenic Runx2. Cardiovascular Drugs and Therapy, 2021. https://doi.org/10.1007/s10557-021-07227-6
  • Amer, A.E., El-Sheakh, A.R., Hamed, M.F., Nader, M.A., Shehatou, G.S.G. Febuxostat attenuates vascular calcification induced by vitamin D3 plus nicotine in rats. European Journal of Pharmaceutical Sciences, 2021, 156, 105580. https://doi.org/10.1016/j.ejps.2020.105580
  • Elshal, M., Abu-Elsaad, N., El-Karef, A., Ibrahim, T.M. Etanercept attenuates immune-mediated hepatitis induced by concanavalin A via differential regulation of the key effector cytokines of CD4+ T cells. Life Sciences, 2021, 277, 119618. https://doi.org/10.1016/j.lfs.2021.119618
  • Mohamed, N.I., Suddek, G.M., El-Kashef, D.H. Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis. International Immunopharmacology, 2021, 99, 108005. https://doi.org/10.1016/j.intimp.2021.108005
  • Abdelhamid, A.M., Elsheakh, A.R., Suddek, G.M. Abdelaziz, R.R. Telmisartan alleviates alcohol-induced liver injury by activation of PPAR-γ/ Nrf-2 crosstalk in mice. International Immunopharmacology, 2021, 99, 107963. https://doi.org/10.1016/j.intimp.2021.107963
  • Nour, O.A., Ghoniem, H.A., Nader, M.A., Suddek, G.M. Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats. European Journal of Pharmacology, 2021, 907, 174257. https://doi.org/10.1016/j.ejphar.2021.174257
  • Habib, S.A., Suddek, G.M., Abdel Rahim, M., Abdelrahman, R.S. The protective effect of protocatechuic acid on hepatotoxicity induced by cisplatin in mice. Life Sciences, 2021, 277, 119485. https://doi.org/10.1016/j.lfs.2021.119485
  • Mohamed, N.I., El-Kashef, D.H., Suddek, G.M. Flavocoxid halts both intestinal and extraintestinal alterations in acetic acid-induced colitis in rats. Environmental Science and Pollution Research, 2021. 29(4):5945-5959. https://doi.org/10.1007/s11356-021-16092-7
  • Sherif, D.A., Makled, M.N., Suddek, G.M. The HIV reverse transcriptase Tenofovir suppressed DMH/HFD-induced colorectal cancer in Wistar rats. Fundamental and Clinical Pharmacology, 2021. 35(6):940-954. https://doi.org/10.1111/fcp.12679
  • Abdelmageed, M.E., Nader, M.A., Zaghloul, M.S. Targeting HMGB1/TLR4/NF-κB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats. European Journal of Pharmacology, 2021, 906, 174279. https://doi.org/10.1016/j.ejphar.2021.174279
  • Serrya, M.S., Nader, M.A., Abdelmageed, M.E. Hepatoprotective effect of the tyrosine kinase inhibitor nilotinib against cyclosporine-A induced liver injury in rats through blocking the Bax/Cytochrome C/caspase-3 apoptotic signaling pathway. Journal of Biochemical and Molecular Toxicology, 2021, 35(6), pp. 1–13. https://doi.org/10.1002/JBT.22764
  • Mohamed, S.A., El-Kashef, D.H., Nader, M.A. Tiron alleviates MPTP-induced Parkinsonism in mice via activation of Keap-1/Nrf2 pathway. Journal of Biochemical and Molecular Toxicology, 2021, 35(3), e22685. https://doi.org/10.1002/jbt.22685
  • Amer, A.E., El-Sheakh, A.R., Hamed, M.F., Nader, M.A., Shehatou, G.S.G. Febuxostat attenuates vascular calcification induced by vitamin D3 plus nicotine in rats. European Journal of Pharmaceutical Sciences, 2021, 156, 105580. https://doi.org/10.1016/j.ejps.2020.105580
  • MH Sharawy, MS El‐Awady, MN Makled. Protective effects of paclitaxel on thioacetamide‐induced liver fibrosis in a rat model. Journal of Biochemical and Molecular Toxicology, 2021, e22745. https://doi.org/10.1002/jbt.22745
  • NME Hassan, GSG Shehatou, HI Kenawy, E Said‏. Dasatinib mitigates renal fibrosis in a rat model of UUO via inhibition of Src/STAT-3/NF-κB signaling‏. Environmental Toxicology and Pharmacology, 2021, 84, 103625. https://doi.org/10.1016/j.etap.2021.103625
  • NME Hassan, E Said, GSG Shehatou. Nifuroxazide suppresses UUO-induced renal fibrosis in rats via inhibiting STAT-3/NF-κB signaling, oxidative stress and inflammation‏. Life Sciences, 2021, 272, 119241‏. https://doi.org/10.1016/j.lfs.2021.119241
  • HMH Ali A El-Emam, George Shehatou, Lamya H Al-Wahaibi. Adamantane-linked isothiourea derivatives suppress the growth of experimental hepatocellular carcinoma via inhibition of TLR4-MyD88-NF-κB signaling‏. American Journal of Cancer Research, 2021, 11 (2), 350-369‏. https://www.ncbi.nlm.nih.gov/pubmed/33575076
  • Al-Sanea, M.M., Obaidullah, A.J., Shaker, M.E., ...Alsubaie, S.A., Abdelgawad, M.A. A new CDK2 inhibitor with 3-hydrazonoindolin-2-one scaffold endowed with anti-breast cancer activity: Design, synthesis, biological evaluation, and in silico insights. Molecules, 2021, 26(2), 412. https://doi.org/10.3390/molecules26020412
  • EA Nazmy, MG Helal, E Said. Nifuroxazide mitigates cholestatic liver injury by synergistic inhibition of Il-6/Β-catenin signaling and enhancement of BSEP and MDRP2 expression. International Immunopharmacology, 2021, 99, 107931. https://doi.org/10.1016/j.intimp.2021.107931
  • M Helal, M Shawky, S Elhusseiny, A Abd Elhameed. Lactoferrin Ameliorates Azithromycin-induced Cardiac Injury: Insight into Oxidative Stress/TLR4/NF-κB Pathway. Journal of Advanced Pharmacy Research, 2021, 5 (2), 285-296. https://dx.doi.org/10.21608/aprh.2021.62735.1122
  • MG Helal, AG Abd Elhameed. Graviola mitigates acetic acid–induced ulcerative colitis in rats: insight on apoptosis and Wnt/Hh signaling crosstalk. Environmental Science and Pollution Research, 2021, 1-14. https://doi.org/10.1007/s11356-021-12716-0
  • MS Serrya, AR El-Sheakh, MN Makled. Evaluation of the therapeutic effects of mycophenolate mofetil targeting Nrf-2 and NLRP3 inflammasome in acetic acid induced ulcerative colitis in rats. Life Sciences, 2021, 271, 119154. https://doi.org/10.1016/j.lfs.2021.119154
  • Eisa, N.H., Khodir, A.E., El-Sherbiny, M., Elsherbiny, N.M., Said, E. Phenethyl isothiocyanate attenuates diabetic nephropathy via modulation of glycative/oxidative/inflammatory signaling in diabetic rats. Biomedicine and Pharmacotherapy, 2021, 142, 111666.
  •  https://doi.org/10.1016/j.biopha.2021.111666
  • Makled, M.N., Said, E. Tranilast abrogates cisplatin-induced testicular and epididymal injuries: An insight into its modulatory impact on apoptosis/proliferation. Journal of Biochemical and Molecular Toxicology, 2021, 35(8), e22817. https://doi.org/10.1002/jbt.22817
  • Alzahrani, S., Said, E., Ajwah, S.M., Qushawy, M., Elsherbiny, N.M. Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury. The Journal of pharmacy and pharmacology, 2021, 73(2), pp. 193–205. https://doi.org/10.1093/jpp/rgaa056
  • Ezzat, D.M., Soliman, A.M., El-Kashef, D.H. Nicorandil mitigates folic acid-induced nephrotoxicity in mice: Role of iNOS and eNOS. Journal of Biochemical and Molecular Toxicology, 2021, 35(4), e22692. https://doi.org/10.1002/jbt.22692
  • Zuchowski, Y., Dalmasso, C., Shawky, N.M., Reckelhoff, J.F. Cardiometabolic consequences of maternal hyperandrogenemia in male offspring. Physiological Reports, 2021, 9(14), e14941. https://dx.doi.org/10.14814%2Fphy2.14941
  • Pichavaram, P., Shawky, N.M., Hartney, T.J., Jun, J.Y., Segar, L. Imatinib improves insulin resistance and inhibits injury-induced neointimal hyperplasia in high fat diet-fed mice. European Journal of Pharmacology, 2021, 890, 173666. https://doi.org/10.1016/j.ejphar.2020.173666
  • Elnfarawy, A.A., Nashy, A.E., Abozaid, A.M., ...Elweshahy, R.H., Abdelrahman, R.S. Vinpocetine attenuates thioacetamide-induced liver fibrosis in rats. Human and Experimental Toxicology, 2021, 40(2), pp. 355–368. https://doi.org/10.1177/0960327120947453
  • Abd Elhameed, A.G. Krill oil and low-dose aspirin combination mitigates experimentally induced silicosis in rats: role of NF-κB/TGF-β1/MMP-9 pathway. Environmental Science and Pollution Research, 2021, 28(15), pp. 19272–19284. https://doi.org/10.1007/s11356-020-11921-7
  • Mazyed, E.A., Helal, D.A., Elkhoudary, M.M., Abd Elhameed, A.G., Yasser, M. Formulation and optimization of nanospanlastics for improving the bioavailability of green tea epigallocatechin gallate. Pharmaceuticals, 2021, 14(1), pp. 1–30, 68. https://doi.org/10.3390/ph14010068
  • Fahmy, E.K., El-Sherbiny, M., Said, E., ...Qushawy, M., Elsherbiny, N. Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2. NeuroToxicology, 2021, 82, pp. 167–176. https://doi.org/10.1016/j.neuro.2020.12.008
  • Samra, Y.A., Amin, M.N., Said, E. Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling. International Immunopharmacology, 2021, 90, 107125. https://doi.org/10.1016/j.intimp.2020.107125
  • Elshaer, S.E., Park, H., Pearson, L., Hill, W.D., Longo, F., and El-Remessy. A.B. Modulation of p75NTR on mesenchymal stem cells increases their vascular protection in retinal ischemia-reperfusion mouse model. Int. J. Mol. Sci., 2021, 22, 829. https://www.mdpi.com/1422-0067/22/2/829
  • Elshaer, S.L., Bahram, S.H., Rajashekar, P., Gangaraju, R., El-Remessy, A.B. Modulation of Mesenchymal Stem Cells for Enhanced Therapeutic Utility in Ischemic Vascular Diseases. Int. J. Mol. Sci., 2021 23(1):249. doi: 10.3390/ijms23010249 (Review article)

 

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