Pharmacology and toxicology Publications 2022

  • Zaghloul, M. S., Elshal, M., Abdelmageed, M. E. (2022). Preventive empagliflozin activity on acute acetic acid-induced ulcerative colitis in rats via modulation of SIRT-1/PI3K/AKT pathway and improving colon barrier. Environmental Toxicology and Pharmacology. https://doi.org/10.1016/j.etap.2022.103833.
  • Elshal, M., Abdelmageed, M.E (2022). Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways. Arch. Pharm. Res. https://doi.org/10.1007/s12272-022-01373-7.
  • Samaha, M.M., Helal, M.G., El-Sherbiny, M., Said, E., Salem, H.A. Diacerein versus adipoRon as adiponectin modulators in experimentally-induced end-stage type 2 diabetes mellitus in rats. Environmental Toxicology and Pharmacology, 2022, 90, 103806. https://doi.org/10.1016/j.etap.2021.103806
  • Mohamed, N.I., El-Kashef, D.H., Suddek, G.M. Flavocoxid halts both intestinal and extraintestinal alterations in acetic acid-induced colitis in rats. Environmental Science and Pollution Research, 2022, 29(4), pp. 5945–5959 https://doi.org/10.1007/s11356-021-16092-7
  • Mohamed, N.I., Suddek, G.M., El-Kashef, D.H. Corrigendum: “Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis”. International Immunopharmacology, 2022, 108575. https://doi.org/10.1016/j.intimp.2022.108575
  • Khaled, S., Makled, M.N., Nader, M.A. Protective effects of propolis extract against nicotine-evoked pulmonary and hepatic damage. Environmental Science and Pollution Research, 2022, 29(4), pp. 5812–5826. https://doi.org/10.1007/s11356-021-16093-6
  • Gomaa, H.A.M., Shaker, M.E., Alzarea, S.I., ...Trembleau, L., Youssif, B.G.M. Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities. Bioorganic Chemistry, 2022, 120, 105616. http://dx.doi.org/10.1016/j.bioorg.2022.105616
  • Shaker, M.E., Hendawy, O.M., El-Mesery, M., Hazem, S.H. The JAK inhibitor ruxolitinib abrogates immune hepatitis instigated by concanavalin A in mice. International Immunopharmacology, 2022, 103, 108463. https://doi.org/10.1016/j.intimp.2021.108463
  • Shaker, M.E., Hamed, M.F., Shaaban, A.A. Digoxin mitigates diethylnitrosamine-induced acute liver injury in mice via limiting production of inflammatory mediators. Saudi Pharmaceutical Journal, 2022. https://doi.org/10.1016/j.jsps.2022.01.007
  • Darwish, S.A., El-Kerdawy, M.M., Elsheakh, A.R., ...Hassan, G.S., Ghaly, M.A. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies. Bioorganic Chemistry, 2022, 120, 105644. https://doi.org/10.1016/j.bioorg.2022.105644
  • Waly, O.M., Saad, K.M., El-Subbagh, H.I., Bayomi, S.M., Ghaly, M.A. Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents. European Journal of Medicinal Chemistry, 2022, 231, 114152 https://doi.org/10.1016/j.ejmech.2022.114152
  • Madkour, A. H., Helal, M. G., Said, E., & Salem, H. A. Dose-dependent renoprotective impact of Lactoferrin against glycerol-induced rhabdomyolysis and acute kidney injury. Life Sciences, 2022, 120646. https://doi.org/10.1016/j.lfs.2022.120646.
  •  Samaha, M. M., Helal, M. G., El-Sherbiny, M., Said, E., & Salem, H. A. Indapamide Increases IRS1 Expression and Modifies Adiponectin/NLRP3/PPARγ Crosstalk in Type 2 Diabetic Rats. Antioxidants, 2022, 11(4), 691. https://doi.org/10.3390/antiox11040691.
  • El-Sherbiny, M., El-Shafey, M., Said, E., Shaker, G. A., El-Dosoky, M., Ebrahim, H. A., ... & Elsherbiny, N. M. Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation. Life, 2022, 12(5), 764. https://doi.org/10.3390/life12050764
  • Abdelrahman, R. S., Abdelsalam, R. A., & Zaghloul, M. S. Beneficial effect of trimetazidine on folic acid‐induced acute kidney injury in mice: Role of HIF‐1α/HO‐1. Journal of Biochemical and Molecular Toxicology, 2022, 36(5), e23011. https://doi.org/10.1002/jbt.23011.
  • Abdelrahman, R. S., & Shawky, N. M. Trimetazidine, a metabolic modulator, attenuates silica‐induced pulmonary fibrosis and decreases lactate levels and LDH activity in rats. Journal of Biochemical and Molecular Toxicology, 2022, e23071. https://doi.org/10.1002/jbt.23071.
  • Abdelrahman, R. S., & El-Tanbouly, G. S. Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/IL-17/IL-23 immunoinflammatory pathway. Toxicology and Applied Pharmacology, 2022, 440, 115931. https://doi.org/10.1016/j.taap.2022.115931.
  • El Sayed, M. T., El-Sharief, M. A., Zarie, E. S., Morsy, N. M., Elsheakh, A. R., Voronkov, A., ... & Hassan, G. S. Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as cyclooxygenase enzyme (COX) inhibitors (vol 28, pg 952, 2018). Bioorganic & medicinal chemistry letters,2022, 61.https://doi.org/10.1016/j.bmcl.2018.01.043
  • El Sayed, M. T., El-Sharief, M. A. S., Zarie, E. S., Morsy, N. M., Elsheakh, A. R., Nayel, M., ... & Abdel-Aziz, H. A. Corrigendum to" Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential Naprosyn® analogs as COX-1 and/or COX-2 inhibitors"[Bioorg. Chem. 76 (2018) 188-201]. Bioorganic chemistry, 2022, 122, 105753. https://doi.org/10.1016/j.bioorg.2022.105753.
  • Makled, M. N., Serrya, M. S., & El‐Sheakh, A. R. Fingolimod ameliorates acetic acid‐induced ulcerative colitis: An insight into its modulatory impact on pro/anti‐inflammatory cytokines and AKT/mTOR signalling. Basic & Clinical Pharmacology & Toxicology, 2022, 130(5), 569-580. https://doi.org/10.1111/bcpt.13720.
  • Al-Wakeel, D. E., El-Kashef, D. H., & Nader, M. A. Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-κB axis. Life Sciences,2022, 120633. https://doi.org/10.1016/j.lfs.2022.120633.
  • Zaghloul, R. A., Zaghloul, A. M., & El-Kashef, D. H. Hepatoprotective effect of Baicalin against thioacetamide-induced cirrhosis in rats: Targeting NOX4/NF-κB/NLRP3 inflammasome signaling pathways. Life Sciences, 2022, 295, 120410. https://doi.org/10.1016/j.lfs.2022.120410.
  • Abdelgawad, M. A., Mohamed, F. E., Lamie, P. F., Bukhari, S. N., Al-Sanea, M. M., Musa, A., ... & Kandeel, M. M. Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells. Bioorganic Chemistry, 2022, 122, 105752. https://doi.org/10.1016/j.bioorg.2022.105752.
  • Shaker, M. E. The contribution of sterile inflammation to the fatty liver disease and the potential therapies. Biomedicine & Pharmacotherapy, 2022, 148, 112789. https://doi.org/10.1016/j.biopha.2022.112789.
  • Shawky, N. M., Dalmasso, C., Ojeda, N. B., Zuchowski, Y., Stachenfeld, N., Alexander, B. T., & Reckelhoff, J. F. Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II. Journal of hypertension, 2022, 40(4), 712-722. https://doi.org/10.1097/HJH.0000000000003067.
  • El-Huneidi, W., Anjum, S., Saleh, M. A., Bustanji, Y., Abu-Gharbieh, E., & Taneera, J. Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake. Molecules, 2022, 27(7), 2102. https://doi.org/10.3390/molecules27072102.
  • Zaghloul, M. S., Elshal, M., & Abdelmageed, M. E. Preventive empagliflozin activity on acute acetic acid-induced ulcerative colitis in rats via modulation of SIRT-1/PI3K/AKT pathway and improving colon barrier. Environmental Toxicology and Pharmacology, 2022, 91, 103833. https://doi.org/10.1016/j.etap.2022.103833.

 

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